Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems

Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a “message in a bottle...

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Detalles Bibliográficos
Autores principales: Ohno, Shin-ichiro, Drummen, Gregor P. C., Kuroda, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783906/
https://www.ncbi.nlm.nih.gov/pubmed/26861303
http://dx.doi.org/10.3390/ijms17020172
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author Ohno, Shin-ichiro
Drummen, Gregor P. C.
Kuroda, Masahiko
author_facet Ohno, Shin-ichiro
Drummen, Gregor P. C.
Kuroda, Masahiko
author_sort Ohno, Shin-ichiro
collection PubMed
description Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a “message in a bottle” to cells in remote locations. The encapsulated molecules are protected from multiple types of degradative enzymes in body fluids, making EVs ideal for delivering drugs. This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems.
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spelling pubmed-47839062016-03-14 Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems Ohno, Shin-ichiro Drummen, Gregor P. C. Kuroda, Masahiko Int J Mol Sci Review Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a “message in a bottle” to cells in remote locations. The encapsulated molecules are protected from multiple types of degradative enzymes in body fluids, making EVs ideal for delivering drugs. This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems. MDPI 2016-02-06 /pmc/articles/PMC4783906/ /pubmed/26861303 http://dx.doi.org/10.3390/ijms17020172 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ohno, Shin-ichiro
Drummen, Gregor P. C.
Kuroda, Masahiko
Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_full Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_fullStr Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_full_unstemmed Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_short Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_sort focus on extracellular vesicles: development of extracellular vesicle-based therapeutic systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783906/
https://www.ncbi.nlm.nih.gov/pubmed/26861303
http://dx.doi.org/10.3390/ijms17020172
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