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Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia

Monocyte chemoattractant protein (MCP)-1 increases in the serum of immunocompetent patients with community-acquired pneumonia (CAP). However, the correlation between the circulating level of MCP-1 and severity of CAP remains unclear. This study investigated differential changes in the plasma MCP-1 l...

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Autores principales: Yong, Kok-Khun, Chang, Jer-Hwa, Chien, Ming-Hsien, Tsao, Shih-Ming, Yu, Ming-Chih, Bai, Kuan-Jen, Tsao, Thomas Chang-Yao, Yang, Shun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783913/
https://www.ncbi.nlm.nih.gov/pubmed/26840299
http://dx.doi.org/10.3390/ijms17020179
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author Yong, Kok-Khun
Chang, Jer-Hwa
Chien, Ming-Hsien
Tsao, Shih-Ming
Yu, Ming-Chih
Bai, Kuan-Jen
Tsao, Thomas Chang-Yao
Yang, Shun-Fa
author_facet Yong, Kok-Khun
Chang, Jer-Hwa
Chien, Ming-Hsien
Tsao, Shih-Ming
Yu, Ming-Chih
Bai, Kuan-Jen
Tsao, Thomas Chang-Yao
Yang, Shun-Fa
author_sort Yong, Kok-Khun
collection PubMed
description Monocyte chemoattractant protein (MCP)-1 increases in the serum of immunocompetent patients with community-acquired pneumonia (CAP). However, the correlation between the circulating level of MCP-1 and severity of CAP remains unclear. This study investigated differential changes in the plasma MCP-1 levels of patients with CAP before and after an antibiotic treatment and further analyzes the association between the CAP severity and MCP-1 levels. We measured the plasma MCP-1 levels of 137 patients with CAP and 74 healthy controls by using a commercial enzyme-linked immunosorbent assay. Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II); confusion, urea level, respiratory rate, blood pressure, and age of >64 years (CURB-65); and pneumonia severity index (PSI) scores were determined for assessing the CAP severity in these patients. The antibiotic treatment reduced the number of white blood cells (WBCs) and neutrophils as well as the level of C-reactive protein (CRP) and MCP-1. The plasma MCP-1 level, but not the CRP level or WBC count, correlated with the CAP severity according to the PSI (r = 0.509, p < 0.001), CURB-65 (r = 0.468, p < 0.001), and APACHE II (r = 0.360, p < 0.001) scores. We concluded that MCP-1 levels act in the development of CAP and are involved in the severity of CAP.
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spelling pubmed-47839132016-03-14 Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia Yong, Kok-Khun Chang, Jer-Hwa Chien, Ming-Hsien Tsao, Shih-Ming Yu, Ming-Chih Bai, Kuan-Jen Tsao, Thomas Chang-Yao Yang, Shun-Fa Int J Mol Sci Article Monocyte chemoattractant protein (MCP)-1 increases in the serum of immunocompetent patients with community-acquired pneumonia (CAP). However, the correlation between the circulating level of MCP-1 and severity of CAP remains unclear. This study investigated differential changes in the plasma MCP-1 levels of patients with CAP before and after an antibiotic treatment and further analyzes the association between the CAP severity and MCP-1 levels. We measured the plasma MCP-1 levels of 137 patients with CAP and 74 healthy controls by using a commercial enzyme-linked immunosorbent assay. Upon initial hospitalization, Acute Physiology and Chronic Health Evaluation II (APACHE II); confusion, urea level, respiratory rate, blood pressure, and age of >64 years (CURB-65); and pneumonia severity index (PSI) scores were determined for assessing the CAP severity in these patients. The antibiotic treatment reduced the number of white blood cells (WBCs) and neutrophils as well as the level of C-reactive protein (CRP) and MCP-1. The plasma MCP-1 level, but not the CRP level or WBC count, correlated with the CAP severity according to the PSI (r = 0.509, p < 0.001), CURB-65 (r = 0.468, p < 0.001), and APACHE II (r = 0.360, p < 0.001) scores. We concluded that MCP-1 levels act in the development of CAP and are involved in the severity of CAP. MDPI 2016-01-29 /pmc/articles/PMC4783913/ /pubmed/26840299 http://dx.doi.org/10.3390/ijms17020179 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yong, Kok-Khun
Chang, Jer-Hwa
Chien, Ming-Hsien
Tsao, Shih-Ming
Yu, Ming-Chih
Bai, Kuan-Jen
Tsao, Thomas Chang-Yao
Yang, Shun-Fa
Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia
title Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia
title_full Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia
title_fullStr Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia
title_full_unstemmed Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia
title_short Plasma Monocyte Chemoattractant Protein-1 Level as a Predictor of the Severity of Community-Acquired Pneumonia
title_sort plasma monocyte chemoattractant protein-1 level as a predictor of the severity of community-acquired pneumonia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783913/
https://www.ncbi.nlm.nih.gov/pubmed/26840299
http://dx.doi.org/10.3390/ijms17020179
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