Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1

Aristolochic acid I (AAI) is a plant drug found in Aristolochia species that causes aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is activated via nitroreduction producing genotoxic N-hydroxyaristolactam, which forms DNA adducts. The majo...

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Detalles Bibliográficos
Autores principales: Milichovský, Jan, Bárta, František, Schmeiser, Heinz H., Arlt, Volker M., Frei, Eva, Stiborová, Marie, Martínek, Václav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783945/
https://www.ncbi.nlm.nih.gov/pubmed/26861298
http://dx.doi.org/10.3390/ijms17020213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783945/
https://www.ncbi.nlm.nih.gov/pubmed/26861298
http://dx.doi.org/10.3390/ijms17020213

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