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Hepatotoxicity by Drugs: The Most Common Implicated Agents
Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). Accordin...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783956/ https://www.ncbi.nlm.nih.gov/pubmed/26861310 http://dx.doi.org/10.3390/ijms17020224 |
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author | Björnsson, Einar S. |
author_facet | Björnsson, Einar S. |
author_sort | Björnsson, Einar S. |
collection | PubMed |
description | Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab. |
format | Online Article Text |
id | pubmed-4783956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47839562016-03-14 Hepatotoxicity by Drugs: The Most Common Implicated Agents Björnsson, Einar S. Int J Mol Sci Review Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab. MDPI 2016-02-06 /pmc/articles/PMC4783956/ /pubmed/26861310 http://dx.doi.org/10.3390/ijms17020224 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Björnsson, Einar S. Hepatotoxicity by Drugs: The Most Common Implicated Agents |
title | Hepatotoxicity by Drugs: The Most Common Implicated Agents |
title_full | Hepatotoxicity by Drugs: The Most Common Implicated Agents |
title_fullStr | Hepatotoxicity by Drugs: The Most Common Implicated Agents |
title_full_unstemmed | Hepatotoxicity by Drugs: The Most Common Implicated Agents |
title_short | Hepatotoxicity by Drugs: The Most Common Implicated Agents |
title_sort | hepatotoxicity by drugs: the most common implicated agents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783956/ https://www.ncbi.nlm.nih.gov/pubmed/26861310 http://dx.doi.org/10.3390/ijms17020224 |
work_keys_str_mv | AT bjornssoneinars hepatotoxicitybydrugsthemostcommonimplicatedagents |