Endocannabinoids as Guardians of Metastasis

Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an ext...

Descripción completa

Detalles Bibliográficos
Autor principal: Tegeder, Irmgard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783962/
https://www.ncbi.nlm.nih.gov/pubmed/26875980
http://dx.doi.org/10.3390/ijms17020230
_version_ 1782420188023488512
author Tegeder, Irmgard
author_facet Tegeder, Irmgard
author_sort Tegeder, Irmgard
collection PubMed
description Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an extent that this manifests in alterations of plasma endocannabinoids in cancer patients, which was mimicked by similar changes in rodent models of local and metastatic cancer. The present topical review summarizes the complexity of endocannabinoid signaling in the context of tumor growth and metastasis.
format Online
Article
Text
id pubmed-4783962
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-47839622016-03-14 Endocannabinoids as Guardians of Metastasis Tegeder, Irmgard Int J Mol Sci Review Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an extent that this manifests in alterations of plasma endocannabinoids in cancer patients, which was mimicked by similar changes in rodent models of local and metastatic cancer. The present topical review summarizes the complexity of endocannabinoid signaling in the context of tumor growth and metastasis. MDPI 2016-02-10 /pmc/articles/PMC4783962/ /pubmed/26875980 http://dx.doi.org/10.3390/ijms17020230 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tegeder, Irmgard
Endocannabinoids as Guardians of Metastasis
title Endocannabinoids as Guardians of Metastasis
title_full Endocannabinoids as Guardians of Metastasis
title_fullStr Endocannabinoids as Guardians of Metastasis
title_full_unstemmed Endocannabinoids as Guardians of Metastasis
title_short Endocannabinoids as Guardians of Metastasis
title_sort endocannabinoids as guardians of metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783962/
https://www.ncbi.nlm.nih.gov/pubmed/26875980
http://dx.doi.org/10.3390/ijms17020230
work_keys_str_mv AT tegederirmgard endocannabinoidsasguardiansofmetastasis

Ejemplares similares