Overexpression of Glucocorticoid Receptor β Enhances Myogenesis and Reduces Catabolic Gene Expression

Unlike the glucocorticoid receptor α (GRα), GR β (GRβ) has a truncated ligand-binding domain that prevents glucocorticoid binding, implicating GRα as the mediator of glucocorticoid-induced skeletal muscle loss. Because GRβ causes glucocorticoid resistance, targeting GRβ may be beneficial in impairin...

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Detalles Bibliográficos
Autores principales: Hinds, Terry D., Peck, Bailey, Shek, Evan, Stroup, Steven, Hinson, Jennifer, Arthur, Susan, Marino, Joseph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783964/
https://www.ncbi.nlm.nih.gov/pubmed/26875982
http://dx.doi.org/10.3390/ijms17020232

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