In Silico Screening Identifies a Novel Potential PARP1 Inhibitor Targeting Synthetic Lethality in Cancer Treatment

Synthetic lethality describes situations in which defects in two different genes or pathways together result in cell death. This concept has been applied to drug development for cancer treatment, as represented by Poly (ADP-ribose) polymerase (PARPs) inhibitors. In the current study, we performed a...

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Detalles Bibliográficos
Autores principales: Li, Jian, Zhou, Nan, Cai, Peiling, Bao, Jinku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783987/
https://www.ncbi.nlm.nih.gov/pubmed/26907257
http://dx.doi.org/10.3390/ijms17020258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783987/
https://www.ncbi.nlm.nih.gov/pubmed/26907257
http://dx.doi.org/10.3390/ijms17020258

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