Effect of lanosterol on human cataract nucleus

AIM: To study the effect of lanosterol on age-related cataractous human lens nuclei. MATERIALS AND METHODS: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at...

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Detalles Bibliográficos
Autores principales: Shanmugam, P Mahesh, Barigali, Aditya, Kadaskar, Jayant, Borgohain, Sandip, Mishra, Divaynsh Kailash Chandra, Ramanjulu, Rajesh, Minija, C K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784074/
https://www.ncbi.nlm.nih.gov/pubmed/26862091
http://dx.doi.org/10.4103/0301-4738.176040
Descripción
Sumario:AIM: To study the effect of lanosterol on age-related cataractous human lens nuclei. MATERIALS AND METHODS: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity. RESULTS: Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days. CONCLUSION: Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei.

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