Effect of lanosterol on human cataract nucleus

AIM: To study the effect of lanosterol on age-related cataractous human lens nuclei. MATERIALS AND METHODS: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at...

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Autores principales: Shanmugam, P Mahesh, Barigali, Aditya, Kadaskar, Jayant, Borgohain, Sandip, Mishra, Divaynsh Kailash Chandra, Ramanjulu, Rajesh, Minija, C K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784074/
https://www.ncbi.nlm.nih.gov/pubmed/26862091
http://dx.doi.org/10.4103/0301-4738.176040
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author Shanmugam, P Mahesh
Barigali, Aditya
Kadaskar, Jayant
Borgohain, Sandip
Mishra, Divaynsh Kailash Chandra
Ramanjulu, Rajesh
Minija, C K
author_facet Shanmugam, P Mahesh
Barigali, Aditya
Kadaskar, Jayant
Borgohain, Sandip
Mishra, Divaynsh Kailash Chandra
Ramanjulu, Rajesh
Minija, C K
author_sort Shanmugam, P Mahesh
collection PubMed
description AIM: To study the effect of lanosterol on age-related cataractous human lens nuclei. MATERIALS AND METHODS: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity. RESULTS: Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days. CONCLUSION: Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei.
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spelling pubmed-47840742016-03-23 Effect of lanosterol on human cataract nucleus Shanmugam, P Mahesh Barigali, Aditya Kadaskar, Jayant Borgohain, Sandip Mishra, Divaynsh Kailash Chandra Ramanjulu, Rajesh Minija, C K Indian J Ophthalmol Original Article AIM: To study the effect of lanosterol on age-related cataractous human lens nuclei. MATERIALS AND METHODS: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity. RESULTS: Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days. CONCLUSION: Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei. Medknow Publications & Media Pvt Ltd 2015-12 /pmc/articles/PMC4784074/ /pubmed/26862091 http://dx.doi.org/10.4103/0301-4738.176040 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Shanmugam, P Mahesh
Barigali, Aditya
Kadaskar, Jayant
Borgohain, Sandip
Mishra, Divaynsh Kailash Chandra
Ramanjulu, Rajesh
Minija, C K
Effect of lanosterol on human cataract nucleus
title Effect of lanosterol on human cataract nucleus
title_full Effect of lanosterol on human cataract nucleus
title_fullStr Effect of lanosterol on human cataract nucleus
title_full_unstemmed Effect of lanosterol on human cataract nucleus
title_short Effect of lanosterol on human cataract nucleus
title_sort effect of lanosterol on human cataract nucleus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784074/
https://www.ncbi.nlm.nih.gov/pubmed/26862091
http://dx.doi.org/10.4103/0301-4738.176040
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