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Establishment of Immortalized BMP2/4 Double Knock‐Out Osteoblastic Cells Is Essential for Study of Osteoblast Growth, Differentiation, and Osteogenesis

Bone morphogenetic proteins 2 and 4 (BMP2/4) are essential for osteoblast differentiation and osteogenesis. Generation of a BMP2/4 dual knock‐out ((ko/ko)) osteoblastic cell line is a valuable asset for studying effects of BMP2/4 on skeletal development. In this study, our goal was to create immorta...

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Detalles Bibliográficos
Autores principales: Wu, Li‐An, Wang, Feng, Donly, Kevin J., Baker, Andrew, Wan, Chunyan, Luo, Daoshu, MacDougall, Mary, Chen, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784166/
https://www.ncbi.nlm.nih.gov/pubmed/26595646
http://dx.doi.org/10.1002/jcp.25266