In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia

KEY POINTS: The mechanism of therapeutic efficacy of flecainide for catecholaminergic polymorphic ventricular tachycardia (CPVT) is unclear. Model predictions suggest that Na(+) channel effects are insufficient to explain flecainide efficacy in CPVT. This study represents a first step toward predict...

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Detalles Bibliográficos
Autores principales: Yang, Pei‐Chi, Moreno, Jonathan D., Miyake, Christina Y., Vaughn‐Behrens, Steven B., Jeng, Mao‐Tsuen, Grandi, Eleonora, Wehrens, Xander H. T., Noskov, Sergei Y., Clancy, Colleen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Computational Physiology and Modelling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784170/
https://www.ncbi.nlm.nih.gov/pubmed/26515697
http://dx.doi.org/10.1113/JP271282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784170/
https://www.ncbi.nlm.nih.gov/pubmed/26515697
http://dx.doi.org/10.1113/JP271282

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