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Autonomic Functioning in Young Adults Born at Extremely Low Birth Weight

Autonomic functioning is altered in infants born at extremely low birth weight (ELBW; <1000 g), but we know little about how such alterations manifest in adulthood. We examined associations between birth weight and resting heart rate (R-R interval), high-frequency (HF) and low-frequency (LF) hear...

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Autores principales: Mathewson, Karen J., Van Lieshout, Ryan J., Saigal, Saroj, Morrison, Katherine M., Boyle, Michael H., Schmidt, Louis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784639/
https://www.ncbi.nlm.nih.gov/pubmed/27335960
http://dx.doi.org/10.1177/2333794X15589560
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author Mathewson, Karen J.
Van Lieshout, Ryan J.
Saigal, Saroj
Morrison, Katherine M.
Boyle, Michael H.
Schmidt, Louis A.
author_facet Mathewson, Karen J.
Van Lieshout, Ryan J.
Saigal, Saroj
Morrison, Katherine M.
Boyle, Michael H.
Schmidt, Louis A.
author_sort Mathewson, Karen J.
collection PubMed
description Autonomic functioning is altered in infants born at extremely low birth weight (ELBW; <1000 g), but we know little about how such alterations manifest in adulthood. We examined associations between birth weight and resting heart rate (R-R interval), high-frequency (HF) and low-frequency (LF) heart rate variability, and systolic (SBP) and diastolic (DBP) blood pressure, in 60 participants (ages 22-26) born at ELBW and free of major neurosensory impairment, and 79 controls born at normal birth weight (NBW; >2500 g). HF in the smallest-born ELBW participants was significantly lower than in NBW controls. In both groups, greater birth weight was associated with higher HF. Among ELBW survivors, lower birth weight predicted faster heart rate and higher DBP, but neither heart rate nor DBP appeared to be well-coordinated with baroreflex activity (LF), the principal mechanism for short-term blood pressure regulation. Adult autonomic regulation may be significantly altered in those born extremely preterm.
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spelling pubmed-47846392016-06-22 Autonomic Functioning in Young Adults Born at Extremely Low Birth Weight Mathewson, Karen J. Van Lieshout, Ryan J. Saigal, Saroj Morrison, Katherine M. Boyle, Michael H. Schmidt, Louis A. Glob Pediatr Health Original Article Autonomic functioning is altered in infants born at extremely low birth weight (ELBW; <1000 g), but we know little about how such alterations manifest in adulthood. We examined associations between birth weight and resting heart rate (R-R interval), high-frequency (HF) and low-frequency (LF) heart rate variability, and systolic (SBP) and diastolic (DBP) blood pressure, in 60 participants (ages 22-26) born at ELBW and free of major neurosensory impairment, and 79 controls born at normal birth weight (NBW; >2500 g). HF in the smallest-born ELBW participants was significantly lower than in NBW controls. In both groups, greater birth weight was associated with higher HF. Among ELBW survivors, lower birth weight predicted faster heart rate and higher DBP, but neither heart rate nor DBP appeared to be well-coordinated with baroreflex activity (LF), the principal mechanism for short-term blood pressure regulation. Adult autonomic regulation may be significantly altered in those born extremely preterm. SAGE Publications 2015-06-09 /pmc/articles/PMC4784639/ /pubmed/27335960 http://dx.doi.org/10.1177/2333794X15589560 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Original Article
Mathewson, Karen J.
Van Lieshout, Ryan J.
Saigal, Saroj
Morrison, Katherine M.
Boyle, Michael H.
Schmidt, Louis A.
Autonomic Functioning in Young Adults Born at Extremely Low Birth Weight
title Autonomic Functioning in Young Adults Born at Extremely Low Birth Weight
title_full Autonomic Functioning in Young Adults Born at Extremely Low Birth Weight
title_fullStr Autonomic Functioning in Young Adults Born at Extremely Low Birth Weight
title_full_unstemmed Autonomic Functioning in Young Adults Born at Extremely Low Birth Weight
title_short Autonomic Functioning in Young Adults Born at Extremely Low Birth Weight
title_sort autonomic functioning in young adults born at extremely low birth weight
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784639/
https://www.ncbi.nlm.nih.gov/pubmed/27335960
http://dx.doi.org/10.1177/2333794X15589560
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