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Tackling the crystallographic structure determination of the COP9 signalosome
The COP9 signalosome (CSN) is an essential multi-protein complex in eukaryotes. CSN is a master regulator of intracellular protein degradation, controlling the vast family of cullin–RING ubiquitin (E3) ligases (CRLs). Important in many cellular processes, CSN has prominent roles in DNA repair, cell-...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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International Union of Crystallography
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784664/ https://www.ncbi.nlm.nih.gov/pubmed/26960120 http://dx.doi.org/10.1107/S2059798316001169 |