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Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases

G-protein-coupled receptors (GPCRs) comprise a large family of cell-surface receptors, which have recently emerged as key players in tumorigenesis, angiogenesis and metastasis. In this review, we discussed our current understanding of the many roles played by GPCRs in general, and particularly Angio...

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Detalles Bibliográficos
Autores principales: Singh, Anukriti, Nunes, Jessica J., Ateeq, Bushra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784721/
https://www.ncbi.nlm.nih.gov/pubmed/25981295
http://dx.doi.org/10.1016/j.ejphar.2015.05.011
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author Singh, Anukriti
Nunes, Jessica J.
Ateeq, Bushra
author_facet Singh, Anukriti
Nunes, Jessica J.
Ateeq, Bushra
author_sort Singh, Anukriti
collection PubMed
description G-protein-coupled receptors (GPCRs) comprise a large family of cell-surface receptors, which have recently emerged as key players in tumorigenesis, angiogenesis and metastasis. In this review, we discussed our current understanding of the many roles played by GPCRs in general, and particularly Angiotensin II type I receptor (AGTR1), a member of the seven-transmembrane-spanning G-protein coupled receptor superfamily, and its significance in breast cancer progression and metastasis. We have also discussed different strategies for targeting AGTR1, and its ligand Angiotension II (Ang II), which might unravel unique opportunities for breast cancer prevention and treatment. For example, AGTR1 blockers (ARBs) which are already in clinical use for treating hypertension, merit further investigation as a therapeutic strategy for AGTR1-positive cancer patients and may have the potential to prevent Ang II-AGTR1 signalling mediated cancer pathogenesis and metastases.
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spelling pubmed-47847212016-03-10 Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases Singh, Anukriti Nunes, Jessica J. Ateeq, Bushra Eur J Pharmacol Article G-protein-coupled receptors (GPCRs) comprise a large family of cell-surface receptors, which have recently emerged as key players in tumorigenesis, angiogenesis and metastasis. In this review, we discussed our current understanding of the many roles played by GPCRs in general, and particularly Angiotensin II type I receptor (AGTR1), a member of the seven-transmembrane-spanning G-protein coupled receptor superfamily, and its significance in breast cancer progression and metastasis. We have also discussed different strategies for targeting AGTR1, and its ligand Angiotension II (Ang II), which might unravel unique opportunities for breast cancer prevention and treatment. For example, AGTR1 blockers (ARBs) which are already in clinical use for treating hypertension, merit further investigation as a therapeutic strategy for AGTR1-positive cancer patients and may have the potential to prevent Ang II-AGTR1 signalling mediated cancer pathogenesis and metastases. Elsevier Science 2015-09-15 /pmc/articles/PMC4784721/ /pubmed/25981295 http://dx.doi.org/10.1016/j.ejphar.2015.05.011 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Singh, Anukriti
Nunes, Jessica J.
Ateeq, Bushra
Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases
title Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases
title_full Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases
title_fullStr Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases
title_full_unstemmed Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases
title_short Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases
title_sort role and therapeutic potential of g-protein coupled receptors in breast cancer progression and metastases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784721/
https://www.ncbi.nlm.nih.gov/pubmed/25981295
http://dx.doi.org/10.1016/j.ejphar.2015.05.011
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