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Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases
G-protein-coupled receptors (GPCRs) comprise a large family of cell-surface receptors, which have recently emerged as key players in tumorigenesis, angiogenesis and metastasis. In this review, we discussed our current understanding of the many roles played by GPCRs in general, and particularly Angio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784721/ https://www.ncbi.nlm.nih.gov/pubmed/25981295 http://dx.doi.org/10.1016/j.ejphar.2015.05.011 |
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author | Singh, Anukriti Nunes, Jessica J. Ateeq, Bushra |
author_facet | Singh, Anukriti Nunes, Jessica J. Ateeq, Bushra |
author_sort | Singh, Anukriti |
collection | PubMed |
description | G-protein-coupled receptors (GPCRs) comprise a large family of cell-surface receptors, which have recently emerged as key players in tumorigenesis, angiogenesis and metastasis. In this review, we discussed our current understanding of the many roles played by GPCRs in general, and particularly Angiotensin II type I receptor (AGTR1), a member of the seven-transmembrane-spanning G-protein coupled receptor superfamily, and its significance in breast cancer progression and metastasis. We have also discussed different strategies for targeting AGTR1, and its ligand Angiotension II (Ang II), which might unravel unique opportunities for breast cancer prevention and treatment. For example, AGTR1 blockers (ARBs) which are already in clinical use for treating hypertension, merit further investigation as a therapeutic strategy for AGTR1-positive cancer patients and may have the potential to prevent Ang II-AGTR1 signalling mediated cancer pathogenesis and metastases. |
format | Online Article Text |
id | pubmed-4784721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47847212016-03-10 Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases Singh, Anukriti Nunes, Jessica J. Ateeq, Bushra Eur J Pharmacol Article G-protein-coupled receptors (GPCRs) comprise a large family of cell-surface receptors, which have recently emerged as key players in tumorigenesis, angiogenesis and metastasis. In this review, we discussed our current understanding of the many roles played by GPCRs in general, and particularly Angiotensin II type I receptor (AGTR1), a member of the seven-transmembrane-spanning G-protein coupled receptor superfamily, and its significance in breast cancer progression and metastasis. We have also discussed different strategies for targeting AGTR1, and its ligand Angiotension II (Ang II), which might unravel unique opportunities for breast cancer prevention and treatment. For example, AGTR1 blockers (ARBs) which are already in clinical use for treating hypertension, merit further investigation as a therapeutic strategy for AGTR1-positive cancer patients and may have the potential to prevent Ang II-AGTR1 signalling mediated cancer pathogenesis and metastases. Elsevier Science 2015-09-15 /pmc/articles/PMC4784721/ /pubmed/25981295 http://dx.doi.org/10.1016/j.ejphar.2015.05.011 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Singh, Anukriti Nunes, Jessica J. Ateeq, Bushra Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases |
title | Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases |
title_full | Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases |
title_fullStr | Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases |
title_full_unstemmed | Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases |
title_short | Role and therapeutic potential of G-protein coupled receptors in breast cancer progression and metastases |
title_sort | role and therapeutic potential of g-protein coupled receptors in breast cancer progression and metastases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784721/ https://www.ncbi.nlm.nih.gov/pubmed/25981295 http://dx.doi.org/10.1016/j.ejphar.2015.05.011 |
work_keys_str_mv | AT singhanukriti roleandtherapeuticpotentialofgproteincoupledreceptorsinbreastcancerprogressionandmetastases AT nunesjessicaj roleandtherapeuticpotentialofgproteincoupledreceptorsinbreastcancerprogressionandmetastases AT ateeqbushra roleandtherapeuticpotentialofgproteincoupledreceptorsinbreastcancerprogressionandmetastases |