Cargando…

Cross‐reactivity of hepatitis C virus specific vaccine‐induced T cells at immunodominant epitopes

Viral diversity is a challenge to the development of a hepatitis C virus (HCV) vaccine. Following vaccination of humans with adenoviral vectors, we determined the capacity of T cells to target common viral variants at immundominant epitopes ex vivo. We identified two major variants for epitopes NS3(...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kelly, Christabel, Swadling, Leo, Brown, Anthony, Capone, Stefania, Folgori, Antonella, Salio, Mariolina, Klenerman, Paul, Barnes, Eleanor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2014
Materias:	Clinical Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784727/ https://www.ncbi.nlm.nih.gov/pubmed/25263407 http://dx.doi.org/10.1002/eji.201444686

Ejemplares similares

Characterizing Hepatitis C Virus–Specific CD4(+) T Cells Following Viral‐Vectored Vaccination, Directly Acting Antivirals, and Spontaneous Viral Cure
por: Hartnell, Felicity, et al.
Publicado: (2020)

Optimising T cell (re)boosting strategies for adenoviral and modified vaccinia Ankara vaccine regimens in humans
por: Capone, Stefania, et al.
Publicado: (2020)

Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8(+) T Cells by Persistent Viruses and Vaccines
por: Gordon, Claire Louse, et al.
Publicado: (2018)

Chronic hepatitis C viral infection subverts vaccine‐induced T‐cell immunity in humans
por: Kelly, Christabel, et al.
Publicado: (2016)

A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein
por: Huang, Jiachen, et al.
Publicado: (2022)

Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection
por: Swadling, Leo, et al.
Publicado: (2016)

Ever closer to a prophylactic vaccine for HCV
por: Swadling, Leo, et al.
Publicado: (2013)

A Novel Approach of Identifying Immunodominant Self and Viral Antigen Cross-Reactive T Cells and Defining the Epitopes They Recognize
por: Yang, Junbao, et al.
Publicado: (2018)

A Novel Vaccine Strategy Employing Serologically Different Chimpanzee Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection
por: Hartnell, Felicity, et al.
Publicado: (2019)

Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
por: Lee, Chloe H., et al.
Publicado: (2020)

Identification of immunodominant T cell epitopes induced by natural Zika virus infection
por: Eickhoff, Christopher S., et al.
Publicado: (2023)

Regulation of Lipid Specific and Vitamin Specific Non-MHC Restricted T Cells by Antigen Presenting Cells and Their Therapeutic Potentials
por: Salio, Mariolina, et al.
Publicado: (2015)

The Immunodominant T-Cell Epitopes of the Mycolyl-Transferases of the Antigen 85 Complex of M. tuberculosis
por: Huygen, Kris
Publicado: (2014)

Harnessing the Power of Invariant Natural Killer T Cells in Cancer Immunotherapy
por: Bedard, Melissa, et al.
Publicado: (2017)

The Immune Modulating Properties of Mucosal-Associated Invariant T Cells
por: Ioannidis, Melina, et al.
Publicado: (2020)

Engineered Viruses as Vaccine Platforms
por: Folgori, Antonella, et al.
Publicado: (2012)

Adenoviral Vector Vaccination Induces a Conserved Program of CD8(+) T Cell Memory Differentiation in Mouse and Man
por: Bolinger, Beatrice, et al.
Publicado: (2015)

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope
por: Cole, David K., et al.
Publicado: (2017)

Autoantibodies Against the Immunodominant Bullous Pemphigoid Epitopes Are Rare in Patients With Dermatitis Herpetiformis and Coeliac Disease
por: Nätynki, Antti, et al.
Publicado: (2020)

MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases
por: Howson, Lauren J., et al.
Publicado: (2015)

T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C
por: Flickinger, John C., et al.
Publicado: (2022)

Antigen‐specific CD8 T cells in cell cycle circulate in the blood after vaccination
por: Simonetti, Sonia, et al.
Publicado: (2019)

Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses
por: Alsaleh, Ghada, et al.
Publicado: (2020)

Immunodominant and Neutralizing Linear B-Cell Epitopes Spanning the Spike and Membrane Proteins of Porcine Epidemic Diarrhea Virus
por: Polyiam, Kanokporn, et al.
Publicado: (2022)

Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus
por: Smyth, Mark, et al.
Publicado: (2021)

In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns
por: Lopes-Ribeiro, Ágata, et al.
Publicado: (2022)

Elevated and cross‐responsive CD1a‐reactive T cells in bee and wasp venom allergic individuals
por: Subramaniam, Sumithra, et al.
Publicado: (2015)

Interferon lambdas: the next cytokine storm
por: Kelly, Christabel, et al.
Publicado: (2011)

Recombinant Influenza Vaccines: Saviors to Overcome Immunodominance
por: Mathew, Nimitha R., et al.
Publicado: (2020)

Hepatitis C Virus Epitope Immunodominance and B Cell Repertoire Diversity
por: Brasher, Nicholas A., et al.
Publicado: (2021)

Mapping Immunodominant Antibody Epitopes of Abrin
por: Alcalay, Ron, et al.
Publicado: (2020)

T Cell Responses Induced by DNA Vaccines Based on the DENV2 E and NS1 Proteins in Mice: Importance in Protection and Immunodominant Epitope Identification
por: Pinto, Paolla B. A., et al.
Publicado: (2019)

Immunodomination of Serotype-Specific CD4+ T-Cell Epitopes Contributed to the Biased Immune Responses Induced by a Tetravalent Measles-Vectored Dengue Vaccine
por: Lin, Tsung-Han, et al.
Publicado: (2020)

A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice
por: Roth, Claude, et al.
Publicado: (2019)

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance
por: Holtappels, Rafaela, et al.
Publicado: (2016)

Immunodominance of Epitopes and Protective Efficacy of HI Antigen Are Differentially Altered Using Different Adjuvants in a Mouse Model of Staphylococcus aureus Bacteremia
por: Chen, Zhifu, et al.
Publicado: (2021)

Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A*02-restricted epitopes that activate CD8(+) T cells
por: Lopes-Ribeiro, Ágata, et al.
Publicado: (2023)

Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection
por: Richards, Katherine A., et al.
Publicado: (2018)

T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses
por: Reynolds, C. J., et al.
Publicado: (2018)

Dm Determines the Cryptic and Immunodominant Fate of T Cell Epitopes
por: Nanda, Navreet K., et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_p42q5kmrjsga3a9mr17rl537db