Cargando…
Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis
BACKGROUND: Previous studies have indicated that intake of dietary flavonoids or flavonoid subclasses is associated with the ovarian cancer risk, but presented controversial results. Therefore, we conducted a meta-analysis to derive a more precise estimation of these associations. METHODS: We perfor...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784737/ https://www.ncbi.nlm.nih.gov/pubmed/26960146 http://dx.doi.org/10.1371/journal.pone.0151134 |
_version_ | 1782420308996653056 |
---|---|
author | Hua, Xiaoli Yu, Lili You, Ruxu Yang, Yu Liao, Jing Chen, Dongsheng Yu, Lixiu |
author_facet | Hua, Xiaoli Yu, Lili You, Ruxu Yang, Yu Liao, Jing Chen, Dongsheng Yu, Lixiu |
author_sort | Hua, Xiaoli |
collection | PubMed |
description | BACKGROUND: Previous studies have indicated that intake of dietary flavonoids or flavonoid subclasses is associated with the ovarian cancer risk, but presented controversial results. Therefore, we conducted a meta-analysis to derive a more precise estimation of these associations. METHODS: We performed a search in PubMed, Google Scholar and ISI Web of Science from their inception to April 25, 2015 to select studies on the association among dietary flavonoids, flavonoid subclasses and ovarian cancer risk. The information was extracted by two independent authors. We assessed the heterogeneity, sensitivity, publication bias and quality of the articles. A random-effects model was used to calculate the pooled risk estimates. RESULTS: Five cohort studies and seven case-control studies were included in the final meta-analysis. We observed that intake of dietary flavonoids can decrease ovarian cancer risk, which was demonstrated by pooled RR (RR = 0.82, 95% CI = 0.68–0.98). In a subgroup analysis by flavonoid subtypes, the ovarian cancer risk was also decreased for isoflavones (RR = 0.67, 95% CI = 0.50–0.92) and flavonols (RR = 0.68, 95% CI = 0.58–0.80). While there was no compelling evidence that consumption of flavones (RR = 0.86, 95% CI = 0.71–1.03) could decrease ovarian cancer risk, which revealed part sources of heterogeneity. The sensitivity analysis indicated stable results, and no publication bias was observed based on the results of Funnel plot analysis and Egger’s test (p = 0.26). CONCLUSIONS: This meta-analysis suggested that consumption of dietary flavonoids and subtypes (isoflavones, flavonols) has a protective effect against ovarian cancer with a reduced risk of ovarian cancer except for flavones consumption. Nevertheless, further investigations on a larger population covering more flavonoid subclasses are warranted. |
format | Online Article Text |
id | pubmed-4784737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47847372016-03-23 Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis Hua, Xiaoli Yu, Lili You, Ruxu Yang, Yu Liao, Jing Chen, Dongsheng Yu, Lixiu PLoS One Research Article BACKGROUND: Previous studies have indicated that intake of dietary flavonoids or flavonoid subclasses is associated with the ovarian cancer risk, but presented controversial results. Therefore, we conducted a meta-analysis to derive a more precise estimation of these associations. METHODS: We performed a search in PubMed, Google Scholar and ISI Web of Science from their inception to April 25, 2015 to select studies on the association among dietary flavonoids, flavonoid subclasses and ovarian cancer risk. The information was extracted by two independent authors. We assessed the heterogeneity, sensitivity, publication bias and quality of the articles. A random-effects model was used to calculate the pooled risk estimates. RESULTS: Five cohort studies and seven case-control studies were included in the final meta-analysis. We observed that intake of dietary flavonoids can decrease ovarian cancer risk, which was demonstrated by pooled RR (RR = 0.82, 95% CI = 0.68–0.98). In a subgroup analysis by flavonoid subtypes, the ovarian cancer risk was also decreased for isoflavones (RR = 0.67, 95% CI = 0.50–0.92) and flavonols (RR = 0.68, 95% CI = 0.58–0.80). While there was no compelling evidence that consumption of flavones (RR = 0.86, 95% CI = 0.71–1.03) could decrease ovarian cancer risk, which revealed part sources of heterogeneity. The sensitivity analysis indicated stable results, and no publication bias was observed based on the results of Funnel plot analysis and Egger’s test (p = 0.26). CONCLUSIONS: This meta-analysis suggested that consumption of dietary flavonoids and subtypes (isoflavones, flavonols) has a protective effect against ovarian cancer with a reduced risk of ovarian cancer except for flavones consumption. Nevertheless, further investigations on a larger population covering more flavonoid subclasses are warranted. Public Library of Science 2016-03-09 /pmc/articles/PMC4784737/ /pubmed/26960146 http://dx.doi.org/10.1371/journal.pone.0151134 Text en © 2016 Hua et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hua, Xiaoli Yu, Lili You, Ruxu Yang, Yu Liao, Jing Chen, Dongsheng Yu, Lixiu Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis |
title | Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis |
title_full | Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis |
title_fullStr | Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis |
title_full_unstemmed | Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis |
title_short | Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis |
title_sort | association among dietary flavonoids, flavonoid subclasses and ovarian cancer risk: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784737/ https://www.ncbi.nlm.nih.gov/pubmed/26960146 http://dx.doi.org/10.1371/journal.pone.0151134 |
work_keys_str_mv | AT huaxiaoli associationamongdietaryflavonoidsflavonoidsubclassesandovariancancerriskametaanalysis AT yulili associationamongdietaryflavonoidsflavonoidsubclassesandovariancancerriskametaanalysis AT youruxu associationamongdietaryflavonoidsflavonoidsubclassesandovariancancerriskametaanalysis AT yangyu associationamongdietaryflavonoidsflavonoidsubclassesandovariancancerriskametaanalysis AT liaojing associationamongdietaryflavonoidsflavonoidsubclassesandovariancancerriskametaanalysis AT chendongsheng associationamongdietaryflavonoidsflavonoidsubclassesandovariancancerriskametaanalysis AT yulixiu associationamongdietaryflavonoidsflavonoidsubclassesandovariancancerriskametaanalysis |