In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components

The antibacterial potential of organic acids and essential oil components against Brachyspira hyodysenteriae, the causative pathogen of swine dysentery, was evaluated. Minimum inhibitory concentrations (MIC) of 15 compounds were determined at pH 7.2 and pH 6.0, using a broth microdilution assay. In...

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Autores principales: VANDE MAELE, Lien, HEYNDRICKX, Marc, MAES, Dominiek, DE PAUW, Nele, MAHU, Maxime, VERLINDEN, Marc, HAESEBROUCK, Freddy, MARTEL, An, PASMANS, Frank, BOYEN, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Bacteriology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785128/
https://www.ncbi.nlm.nih.gov/pubmed/26369432
http://dx.doi.org/10.1292/jvms.15-0341
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author VANDE MAELE, Lien
HEYNDRICKX, Marc
MAES, Dominiek
DE PAUW, Nele
MAHU, Maxime
VERLINDEN, Marc
HAESEBROUCK, Freddy
MARTEL, An
PASMANS, Frank
BOYEN, Filip
author_facet VANDE MAELE, Lien
HEYNDRICKX, Marc
MAES, Dominiek
DE PAUW, Nele
MAHU, Maxime
VERLINDEN, Marc
HAESEBROUCK, Freddy
MARTEL, An
PASMANS, Frank
BOYEN, Filip
author_sort VANDE MAELE, Lien
collection PubMed
description The antibacterial potential of organic acids and essential oil components against Brachyspira hyodysenteriae, the causative pathogen of swine dysentery, was evaluated. Minimum inhibitory concentrations (MIC) of 15 compounds were determined at pH 7.2 and pH 6.0, using a broth microdilution assay. In addition, possible synergism was determined. MIC values for the three tested strains were similar. For organic acids, MIC values at pH 6.0 were lower than at pH 7.2. B. hyodysenteriae was most sensitive to cinnamaldehyde and lauric acid, with MIC values <1.5 mM. Most antibacterial effects of binary combinations were additive, however, for thymol and carvacrol, synergism could be observed. In vitro results demonstrate the antibacterial action of certain essential oil components and organic acids against B. hyodysenteriae.
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spelling pubmed-47851282016-03-10 In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components VANDE MAELE, Lien HEYNDRICKX, Marc MAES, Dominiek DE PAUW, Nele MAHU, Maxime VERLINDEN, Marc HAESEBROUCK, Freddy MARTEL, An PASMANS, Frank BOYEN, Filip J Vet Med Sci Bacteriology The antibacterial potential of organic acids and essential oil components against Brachyspira hyodysenteriae, the causative pathogen of swine dysentery, was evaluated. Minimum inhibitory concentrations (MIC) of 15 compounds were determined at pH 7.2 and pH 6.0, using a broth microdilution assay. In addition, possible synergism was determined. MIC values for the three tested strains were similar. For organic acids, MIC values at pH 6.0 were lower than at pH 7.2. B. hyodysenteriae was most sensitive to cinnamaldehyde and lauric acid, with MIC values <1.5 mM. Most antibacterial effects of binary combinations were additive, however, for thymol and carvacrol, synergism could be observed. In vitro results demonstrate the antibacterial action of certain essential oil components and organic acids against B. hyodysenteriae. The Japanese Society of Veterinary Science 2015-09-14 2016-02 /pmc/articles/PMC4785128/ /pubmed/26369432 http://dx.doi.org/10.1292/jvms.15-0341 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Bacteriology
VANDE MAELE, Lien
HEYNDRICKX, Marc
MAES, Dominiek
DE PAUW, Nele
MAHU, Maxime
VERLINDEN, Marc
HAESEBROUCK, Freddy
MARTEL, An
PASMANS, Frank
BOYEN, Filip
In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components
title In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components
title_full In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components
title_fullStr In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components
title_full_unstemmed In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components
title_short In vitro susceptibility of Brachyspira hyodysenteriae to organic acids and essential oil components
title_sort in vitro susceptibility of brachyspira hyodysenteriae to organic acids and essential oil components
topic Bacteriology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785128/
https://www.ncbi.nlm.nih.gov/pubmed/26369432
http://dx.doi.org/10.1292/jvms.15-0341
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