Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa

The photoreceptor cell death associated with the various genetic forms of retinitis pigmentosa (RP) is currently untreatable and leads to partial or complete vision loss. Carnosic acid (CA) upregulates endogenous antioxidant enzymes and has proven neuroprotective in studies of neurodegenerative mode...

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Autores principales: Kang, Kai, Tarchick, Matthew J., Yu, Xiaoshan, Beight, Craig, Bu, Ping, Yu, Minzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785376/
https://www.ncbi.nlm.nih.gov/pubmed/26961159
http://dx.doi.org/10.1038/srep22632
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author Kang, Kai
Tarchick, Matthew J.
Yu, Xiaoshan
Beight, Craig
Bu, Ping
Yu, Minzhong
author_facet Kang, Kai
Tarchick, Matthew J.
Yu, Xiaoshan
Beight, Craig
Bu, Ping
Yu, Minzhong
author_sort Kang, Kai
collection PubMed
description The photoreceptor cell death associated with the various genetic forms of retinitis pigmentosa (RP) is currently untreatable and leads to partial or complete vision loss. Carnosic acid (CA) upregulates endogenous antioxidant enzymes and has proven neuroprotective in studies of neurodegenerative models affecting the brain. In this study, we examined the potential effect of CA on photoreceptor death in the Pde6b(rd10) mouse model of RP. Our data shows that CA provided morphological and functional preservation of photoreceptors. CA appears to exert its neuroprotective effects through inhibition of oxidative stress and endoplasmic reticulum stress.
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spelling pubmed-47853762016-03-11 Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa Kang, Kai Tarchick, Matthew J. Yu, Xiaoshan Beight, Craig Bu, Ping Yu, Minzhong Sci Rep Article The photoreceptor cell death associated with the various genetic forms of retinitis pigmentosa (RP) is currently untreatable and leads to partial or complete vision loss. Carnosic acid (CA) upregulates endogenous antioxidant enzymes and has proven neuroprotective in studies of neurodegenerative models affecting the brain. In this study, we examined the potential effect of CA on photoreceptor death in the Pde6b(rd10) mouse model of RP. Our data shows that CA provided morphological and functional preservation of photoreceptors. CA appears to exert its neuroprotective effects through inhibition of oxidative stress and endoplasmic reticulum stress. Nature Publishing Group 2016-03-10 /pmc/articles/PMC4785376/ /pubmed/26961159 http://dx.doi.org/10.1038/srep22632 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Kang, Kai
Tarchick, Matthew J.
Yu, Xiaoshan
Beight, Craig
Bu, Ping
Yu, Minzhong
Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa
title Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa
title_full Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa
title_fullStr Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa
title_full_unstemmed Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa
title_short Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa
title_sort carnosic acid slows photoreceptor degeneration in the pde6b(rd10) mouse model of retinitis pigmentosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785376/
https://www.ncbi.nlm.nih.gov/pubmed/26961159
http://dx.doi.org/10.1038/srep22632
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