NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease

Oxidative stress and aberrant accumulation of misfolded proteins in the cytosol are key pathological features associated with Parkinson’s disease (PD). NADPH oxidase (Nox2) is upregulated in the pathogenesis of PD; however, the underlying mechanism(s) of Nox2-mediated oxidative stress in PD pathogen...

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Detalles Bibliográficos
Autores principales: Pal, Rituraj, Bajaj, Lakshya, Sharma, Jaiprakash, Palmieri, Michela, Di Ronza, Alberto, Lotfi, Parisa, Chaudhury, Arindam, Neilson, Joel, Sardiello, Marco, Rodney, George G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785399/
https://www.ncbi.nlm.nih.gov/pubmed/26960433
http://dx.doi.org/10.1038/srep22866

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