The three-dimensional structure of Clostridium absonum 7α-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition

7α-hydroxysteroid dehydrogenase (7α-HSDH) can catalyse the oxidation of C7 α-OH of the steroid nucleus in the bile acid metabolism. In the paper we determined the crystal structure of 7α-HSDH from Clostridium absonum (CA 7α-HSDH) complexed with taurochenodeoxycholic acid (TCDCA) and NADP(+) by X-ray...

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Detalles Bibliográficos
Autores principales: Lou, Deshuai, Wang, Bochu, Tan, Jun, Zhu, Liancai, Cen, Xiaoxi, Ji, Qingzhi, Wang, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785404/
https://www.ncbi.nlm.nih.gov/pubmed/26961171
http://dx.doi.org/10.1038/srep22885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785404/
https://www.ncbi.nlm.nih.gov/pubmed/26961171
http://dx.doi.org/10.1038/srep22885

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