Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations

Two OCA2 polymorphisms (rs1800414 and rs74653330) have been associated with pigmentation in East Asians. We explored the distribution of these markers in a panel of samples from populations around the world. The derived allele of rs1800414 has high frequencies in a broad East-Asian region, whereas t...

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Autores principales: Murray, Nicole, Norton, Heather L, Parra, Esteban J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Data Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785538/
https://www.ncbi.nlm.nih.gov/pubmed/27081560
http://dx.doi.org/10.1038/hgv.2015.58
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author Murray, Nicole
Norton, Heather L
Parra, Esteban J
author_facet Murray, Nicole
Norton, Heather L
Parra, Esteban J
author_sort Murray, Nicole
collection PubMed
description Two OCA2 polymorphisms (rs1800414 and rs74653330) have been associated with pigmentation in East Asians. We explored the distribution of these markers in a panel of samples from populations around the world. The derived allele of rs1800414 has high frequencies in a broad East-Asian region, whereas the derived allele of rs74653330 is primarily restricted to northern East Asia. Our data suggest that these polymorphisms may have been selected independently in different regions of East Asia.
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spelling pubmed-47855382016-04-14 Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations Murray, Nicole Norton, Heather L Parra, Esteban J Hum Genome Var Data Report Two OCA2 polymorphisms (rs1800414 and rs74653330) have been associated with pigmentation in East Asians. We explored the distribution of these markers in a panel of samples from populations around the world. The derived allele of rs1800414 has high frequencies in a broad East-Asian region, whereas the derived allele of rs74653330 is primarily restricted to northern East Asia. Our data suggest that these polymorphisms may have been selected independently in different regions of East Asia. Nature Publishing Group 2015-12-10 /pmc/articles/PMC4785538/ /pubmed/27081560 http://dx.doi.org/10.1038/hgv.2015.58 Text en Copyright © 2015 Official journal of the Japan Society of Human Genetics http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Data Report
Murray, Nicole
Norton, Heather L
Parra, Esteban J
Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations
title Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations
title_full Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations
title_fullStr Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations
title_full_unstemmed Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations
title_short Distribution of two OCA2 polymorphisms associated with pigmentation in East-Asian populations
title_sort distribution of two oca2 polymorphisms associated with pigmentation in east-asian populations
topic Data Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785538/
https://www.ncbi.nlm.nih.gov/pubmed/27081560
http://dx.doi.org/10.1038/hgv.2015.58
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