An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population

Narcolepsy without cataplexy (NA w/o CA) (narcolepsy type 2) is a lifelong disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep abnormalities, but no cataplexy. In the present study, we examined the human leukocyte antigen HLA-DQB1 in 160 Japanese patients with N...

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Detalles Bibliográficos
Autores principales: Miyagawa, Taku, Toyoda, Hiromi, Kanbayashi, Takashi, Imanishi, Aya, Sagawa, Yohei, Kotorii, Nozomu, Kotorii, Tatayu, Hashizume, Yuji, Ogi, Kimihiro, Hiejima, Hiroshi, Kamei, Yuichi, Hida, Akiko, Miyamoto, Masayuki, Ikegami, Azusa, Wada, Yamato, Takami, Masanori, Fujimura, Yota, Tamura, Yoshiyuki, Omata, Naoto, Masuya, Yasuhiro, Kondo, Hideaki, Moriya, Shunpei, Furuya, Hirokazu, Kato, Mitsuhiro, Kojima, Hiroto, Kashiwase, Koichi, Saji, Hiroh, Khor, Seik-Soon, Yamasaki, Maria, Ishigooka, Jun, Wada, Yuji, Chiba, Shigeru, Yamada, Naoto, Okawa, Masako, Kuroda, Kenji, Kume, Kazuhiko, Hirata, Koichi, Uchimura, Naohisa, Shimizu, Tetsuo, Inoue, Yuichi, Honda, Yutaka, Mishima, Kazuo, Honda, Makoto, Tokunaga, Katsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Data Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785567/
https://www.ncbi.nlm.nih.gov/pubmed/27081540
http://dx.doi.org/10.1038/hgv.2015.31
Descripción
Sumario:Narcolepsy without cataplexy (NA w/o CA) (narcolepsy type 2) is a lifelong disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep abnormalities, but no cataplexy. In the present study, we examined the human leukocyte antigen HLA-DQB1 in 160 Japanese patients with NA w/o CA and 1,418 control subjects. Frequencies of DQB1*06:02 were significantly higher in patients with NA w/o CA compared with controls (allele frequency: 16.6 vs. 7.8%, P=1.1×10(−7), odds ratio (OR)=2.36; carrier frequency: 31.3 vs. 14.7%, P=7.6×10(−8), OR=2.64). Distributions of HLA-DQB1 alleles other than DQB1*06:02 were compared between NA w/o CA and narcolepsy with cataplexy (NA-CA) to assess whether the genetic backgrounds of the two diseases have similarities. The distribution of the HLA-DQB1 alleles in DQB1*06:02-negative NA w/o CA was significantly different from that in NA-CA (P=5.8×10(−7)). On the other hand, the patterns of the HLA-DQB1 alleles were similar between DQB1*06:02-positive NA w/o CA and NA-CA. HLA-DQB1 analysis was also performed in 186 Japanese patients with idiopathic hypersomnia (IHS) with/without long sleep time, but no significant associations were observed.

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