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An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population
Narcolepsy without cataplexy (NA w/o CA) (narcolepsy type 2) is a lifelong disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep abnormalities, but no cataplexy. In the present study, we examined the human leukocyte antigen HLA-DQB1 in 160 Japanese patients with N...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785567/ https://www.ncbi.nlm.nih.gov/pubmed/27081540 http://dx.doi.org/10.1038/hgv.2015.31 |
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| author | Miyagawa, Taku Toyoda, Hiromi Kanbayashi, Takashi Imanishi, Aya Sagawa, Yohei Kotorii, Nozomu Kotorii, Tatayu Hashizume, Yuji Ogi, Kimihiro Hiejima, Hiroshi Kamei, Yuichi Hida, Akiko Miyamoto, Masayuki Ikegami, Azusa Wada, Yamato Takami, Masanori Fujimura, Yota Tamura, Yoshiyuki Omata, Naoto Masuya, Yasuhiro Kondo, Hideaki Moriya, Shunpei Furuya, Hirokazu Kato, Mitsuhiro Kojima, Hiroto Kashiwase, Koichi Saji, Hiroh Khor, Seik-Soon Yamasaki, Maria Ishigooka, Jun Wada, Yuji Chiba, Shigeru Yamada, Naoto Okawa, Masako Kuroda, Kenji Kume, Kazuhiko Hirata, Koichi Uchimura, Naohisa Shimizu, Tetsuo Inoue, Yuichi Honda, Yutaka Mishima, Kazuo Honda, Makoto Tokunaga, Katsushi |
| author_facet | Miyagawa, Taku Toyoda, Hiromi Kanbayashi, Takashi Imanishi, Aya Sagawa, Yohei Kotorii, Nozomu Kotorii, Tatayu Hashizume, Yuji Ogi, Kimihiro Hiejima, Hiroshi Kamei, Yuichi Hida, Akiko Miyamoto, Masayuki Ikegami, Azusa Wada, Yamato Takami, Masanori Fujimura, Yota Tamura, Yoshiyuki Omata, Naoto Masuya, Yasuhiro Kondo, Hideaki Moriya, Shunpei Furuya, Hirokazu Kato, Mitsuhiro Kojima, Hiroto Kashiwase, Koichi Saji, Hiroh Khor, Seik-Soon Yamasaki, Maria Ishigooka, Jun Wada, Yuji Chiba, Shigeru Yamada, Naoto Okawa, Masako Kuroda, Kenji Kume, Kazuhiko Hirata, Koichi Uchimura, Naohisa Shimizu, Tetsuo Inoue, Yuichi Honda, Yutaka Mishima, Kazuo Honda, Makoto Tokunaga, Katsushi |
| author_sort | Miyagawa, Taku |
| collection | PubMed |
| description | Narcolepsy without cataplexy (NA w/o CA) (narcolepsy type 2) is a lifelong disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep abnormalities, but no cataplexy. In the present study, we examined the human leukocyte antigen HLA-DQB1 in 160 Japanese patients with NA w/o CA and 1,418 control subjects. Frequencies of DQB1*06:02 were significantly higher in patients with NA w/o CA compared with controls (allele frequency: 16.6 vs. 7.8%, P=1.1×10(−7), odds ratio (OR)=2.36; carrier frequency: 31.3 vs. 14.7%, P=7.6×10(−8), OR=2.64). Distributions of HLA-DQB1 alleles other than DQB1*06:02 were compared between NA w/o CA and narcolepsy with cataplexy (NA-CA) to assess whether the genetic backgrounds of the two diseases have similarities. The distribution of the HLA-DQB1 alleles in DQB1*06:02-negative NA w/o CA was significantly different from that in NA-CA (P=5.8×10(−7)). On the other hand, the patterns of the HLA-DQB1 alleles were similar between DQB1*06:02-positive NA w/o CA and NA-CA. HLA-DQB1 analysis was also performed in 186 Japanese patients with idiopathic hypersomnia (IHS) with/without long sleep time, but no significant associations were observed. |
| format | Online Article Text |
| id | pubmed-4785567 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47855672016-04-14 An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population Miyagawa, Taku Toyoda, Hiromi Kanbayashi, Takashi Imanishi, Aya Sagawa, Yohei Kotorii, Nozomu Kotorii, Tatayu Hashizume, Yuji Ogi, Kimihiro Hiejima, Hiroshi Kamei, Yuichi Hida, Akiko Miyamoto, Masayuki Ikegami, Azusa Wada, Yamato Takami, Masanori Fujimura, Yota Tamura, Yoshiyuki Omata, Naoto Masuya, Yasuhiro Kondo, Hideaki Moriya, Shunpei Furuya, Hirokazu Kato, Mitsuhiro Kojima, Hiroto Kashiwase, Koichi Saji, Hiroh Khor, Seik-Soon Yamasaki, Maria Ishigooka, Jun Wada, Yuji Chiba, Shigeru Yamada, Naoto Okawa, Masako Kuroda, Kenji Kume, Kazuhiko Hirata, Koichi Uchimura, Naohisa Shimizu, Tetsuo Inoue, Yuichi Honda, Yutaka Mishima, Kazuo Honda, Makoto Tokunaga, Katsushi Hum Genome Var Data Report Narcolepsy without cataplexy (NA w/o CA) (narcolepsy type 2) is a lifelong disorder characterized by excessive daytime sleepiness and rapid eye movement (REM) sleep abnormalities, but no cataplexy. In the present study, we examined the human leukocyte antigen HLA-DQB1 in 160 Japanese patients with NA w/o CA and 1,418 control subjects. Frequencies of DQB1*06:02 were significantly higher in patients with NA w/o CA compared with controls (allele frequency: 16.6 vs. 7.8%, P=1.1×10(−7), odds ratio (OR)=2.36; carrier frequency: 31.3 vs. 14.7%, P=7.6×10(−8), OR=2.64). Distributions of HLA-DQB1 alleles other than DQB1*06:02 were compared between NA w/o CA and narcolepsy with cataplexy (NA-CA) to assess whether the genetic backgrounds of the two diseases have similarities. The distribution of the HLA-DQB1 alleles in DQB1*06:02-negative NA w/o CA was significantly different from that in NA-CA (P=5.8×10(−7)). On the other hand, the patterns of the HLA-DQB1 alleles were similar between DQB1*06:02-positive NA w/o CA and NA-CA. HLA-DQB1 analysis was also performed in 186 Japanese patients with idiopathic hypersomnia (IHS) with/without long sleep time, but no significant associations were observed. Nature Publishing Group 2015-09-17 /pmc/articles/PMC4785567/ /pubmed/27081540 http://dx.doi.org/10.1038/hgv.2015.31 Text en Copyright © 2015 The Japan Society of Human Genetics http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Data Report Miyagawa, Taku Toyoda, Hiromi Kanbayashi, Takashi Imanishi, Aya Sagawa, Yohei Kotorii, Nozomu Kotorii, Tatayu Hashizume, Yuji Ogi, Kimihiro Hiejima, Hiroshi Kamei, Yuichi Hida, Akiko Miyamoto, Masayuki Ikegami, Azusa Wada, Yamato Takami, Masanori Fujimura, Yota Tamura, Yoshiyuki Omata, Naoto Masuya, Yasuhiro Kondo, Hideaki Moriya, Shunpei Furuya, Hirokazu Kato, Mitsuhiro Kojima, Hiroto Kashiwase, Koichi Saji, Hiroh Khor, Seik-Soon Yamasaki, Maria Ishigooka, Jun Wada, Yuji Chiba, Shigeru Yamada, Naoto Okawa, Masako Kuroda, Kenji Kume, Kazuhiko Hirata, Koichi Uchimura, Naohisa Shimizu, Tetsuo Inoue, Yuichi Honda, Yutaka Mishima, Kazuo Honda, Makoto Tokunaga, Katsushi An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population |
| title | An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population |
| title_full | An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population |
| title_fullStr | An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population |
| title_full_unstemmed | An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population |
| title_short | An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population |
| title_sort | association analysis of hla-dqb1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a japanese population |
| topic | Data Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785567/ https://www.ncbi.nlm.nih.gov/pubmed/27081540 http://dx.doi.org/10.1038/hgv.2015.31 |
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