Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer’s disease

Recently, mutations in phospholipase D3 (PLD3) were reported in late-onset Alzheimer's disease (AD). By screening the coding regions of PLD3 for variants in a European cohort of 1,089 AD cases, 182 individuals with frontotemporal lobar degeneration and 1,456 controls, we identified 32 variants...

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Detalles Bibliográficos
Autores principales: Schulte, Eva C, Kurz, Alexander, Alexopoulos, Panagiotis, Hampel, Harald, Peters, Annette, Gieger, Christian, Rujescu, Dan, Diehl-Schmid, Janine, Winkelmann, Juliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Data Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785568/
https://www.ncbi.nlm.nih.gov/pubmed/27081517
http://dx.doi.org/10.1038/hgv.2014.28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785568/
https://www.ncbi.nlm.nih.gov/pubmed/27081517
http://dx.doi.org/10.1038/hgv.2014.28

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