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Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative

BACKGROUND: The thieno[2,3-b]pyridines were discovered by virtual high throughput screening as potential inhibitors of phospholipase C (PLC) isoforms and showed potent growth inhibitory effects in National Cancer Institute’s human tumour cell line panel (NCI60). The mechanism of the anti-proliferati...

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Detalles Bibliográficos
Autores principales:	Reynisson, Jóhannes, Jaiswal, Jagdish K., Barker, David, D’mello, Stacey A. N., Denny, William A., Baguley, Bruce C., Leung, Euphemia Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785615/ https://www.ncbi.nlm.nih.gov/pubmed/26966420 http://dx.doi.org/10.1186/s12935-016-0293-6

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