Cargando…
The effect of intravitreal bevacizumab and ranibizumab on macular edema of the contralateral eye: A comparative study of two anti-VEGFs
PURPOSE: To compare the effects of bevacizumab and ranibizumab on the visual function and macular thickness in the contralateral (untreated) eye of patients with bilateral diabetic macular edema (DME). MATERIALS AND METHODS: Thirty-nine patients with bilateral DME, who had been treated with both bev...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785708/ https://www.ncbi.nlm.nih.gov/pubmed/27013828 http://dx.doi.org/10.4103/0974-620X.176100 |
_version_ | 1782420451898687488 |
---|---|
author | Bakbak, Berker Ozturk, Banu Turgut Gonul, Saban Gedik, Sansal |
author_facet | Bakbak, Berker Ozturk, Banu Turgut Gonul, Saban Gedik, Sansal |
author_sort | Bakbak, Berker |
collection | PubMed |
description | PURPOSE: To compare the effects of bevacizumab and ranibizumab on the visual function and macular thickness in the contralateral (untreated) eye of patients with bilateral diabetic macular edema (DME). MATERIALS AND METHODS: Thirty-nine patients with bilateral DME, who had been treated with both bevacizumab and ranibizumab in the same eye, were considered retrospectively for this study. Recorded outcome measurements included the best-corrected visual acuity (BCVA) assessment with the Early Treatment Diabetic Retinopathy Study (ETDRS) chart and the central subfield macular thickness (CSMT) measurement of the contralateral, uninjected eye before and at 4 weeks after the injections. RESULTS: The median BCVA of the uninjected eye was 50 ETDRS letters and the median CSMT was 459 μm preceding the bevacizumab injection whereas at the control appointment, 4 weeks after the injection, the median BCVA had increased to 52 letters (P = 0.098), and the median CSMT had decreased to 390 μm (P = 0.036). The mean interval between the bevacizumab and ranibizumab treatments was 4.79 1.52 months. The measurements of the untreated eye after the ranibizumab treatment showed that the median BCVA decreased from 55 to 52 letters, and the median CSMT increased from 361 μm to 418 μm (P = 0.148 and P = 0.109, respectively). CONCLUSIONS: In contrast to ranibizumab, the intravitreal administration of bevacizumab resulted in a statistically significant decrease in macular thickness in the untreated eye in patients with bilateral DME. |
format | Online Article Text |
id | pubmed-4785708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47857082016-03-24 The effect of intravitreal bevacizumab and ranibizumab on macular edema of the contralateral eye: A comparative study of two anti-VEGFs Bakbak, Berker Ozturk, Banu Turgut Gonul, Saban Gedik, Sansal Oman J Ophthalmol Original Article PURPOSE: To compare the effects of bevacizumab and ranibizumab on the visual function and macular thickness in the contralateral (untreated) eye of patients with bilateral diabetic macular edema (DME). MATERIALS AND METHODS: Thirty-nine patients with bilateral DME, who had been treated with both bevacizumab and ranibizumab in the same eye, were considered retrospectively for this study. Recorded outcome measurements included the best-corrected visual acuity (BCVA) assessment with the Early Treatment Diabetic Retinopathy Study (ETDRS) chart and the central subfield macular thickness (CSMT) measurement of the contralateral, uninjected eye before and at 4 weeks after the injections. RESULTS: The median BCVA of the uninjected eye was 50 ETDRS letters and the median CSMT was 459 μm preceding the bevacizumab injection whereas at the control appointment, 4 weeks after the injection, the median BCVA had increased to 52 letters (P = 0.098), and the median CSMT had decreased to 390 μm (P = 0.036). The mean interval between the bevacizumab and ranibizumab treatments was 4.79 1.52 months. The measurements of the untreated eye after the ranibizumab treatment showed that the median BCVA decreased from 55 to 52 letters, and the median CSMT increased from 361 μm to 418 μm (P = 0.148 and P = 0.109, respectively). CONCLUSIONS: In contrast to ranibizumab, the intravitreal administration of bevacizumab resulted in a statistically significant decrease in macular thickness in the untreated eye in patients with bilateral DME. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4785708/ /pubmed/27013828 http://dx.doi.org/10.4103/0974-620X.176100 Text en Copyright: © Oman Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Bakbak, Berker Ozturk, Banu Turgut Gonul, Saban Gedik, Sansal The effect of intravitreal bevacizumab and ranibizumab on macular edema of the contralateral eye: A comparative study of two anti-VEGFs |
title | The effect of intravitreal bevacizumab and ranibizumab on macular edema of the contralateral eye: A comparative study of two anti-VEGFs |
title_full | The effect of intravitreal bevacizumab and ranibizumab on macular edema of the contralateral eye: A comparative study of two anti-VEGFs |
title_fullStr | The effect of intravitreal bevacizumab and ranibizumab on macular edema of the contralateral eye: A comparative study of two anti-VEGFs |
title_full_unstemmed | The effect of intravitreal bevacizumab and ranibizumab on macular edema of the contralateral eye: A comparative study of two anti-VEGFs |
title_short | The effect of intravitreal bevacizumab and ranibizumab on macular edema of the contralateral eye: A comparative study of two anti-VEGFs |
title_sort | effect of intravitreal bevacizumab and ranibizumab on macular edema of the contralateral eye: a comparative study of two anti-vegfs |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785708/ https://www.ncbi.nlm.nih.gov/pubmed/27013828 http://dx.doi.org/10.4103/0974-620X.176100 |
work_keys_str_mv | AT bakbakberker theeffectofintravitrealbevacizumabandranibizumabonmacularedemaofthecontralateraleyeacomparativestudyoftwoantivegfs AT ozturkbanuturgut theeffectofintravitrealbevacizumabandranibizumabonmacularedemaofthecontralateraleyeacomparativestudyoftwoantivegfs AT gonulsaban theeffectofintravitrealbevacizumabandranibizumabonmacularedemaofthecontralateraleyeacomparativestudyoftwoantivegfs AT gediksansal theeffectofintravitrealbevacizumabandranibizumabonmacularedemaofthecontralateraleyeacomparativestudyoftwoantivegfs AT bakbakberker effectofintravitrealbevacizumabandranibizumabonmacularedemaofthecontralateraleyeacomparativestudyoftwoantivegfs AT ozturkbanuturgut effectofintravitrealbevacizumabandranibizumabonmacularedemaofthecontralateraleyeacomparativestudyoftwoantivegfs AT gonulsaban effectofintravitrealbevacizumabandranibizumabonmacularedemaofthecontralateraleyeacomparativestudyoftwoantivegfs AT gediksansal effectofintravitrealbevacizumabandranibizumabonmacularedemaofthecontralateraleyeacomparativestudyoftwoantivegfs |