Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia

BACKGROUND: Diamond–Blackfan anemia (DBA) was the first ribosomopathy associated with mutations in ribosome protein (RP) genes. The clinical phenotypes of DBA include failure of erythropoiesis, congenital anomalies and cancer predisposition. Mutations in RPL5 are reported in approximately 9 ~ 21 % o...

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Detalles Bibliográficos
Autores principales: Wan, Yang, Zhang, Qian, Zhang, Zhaojun, Song, Binfeng, Wang, Xiaomin, Zhang, Yingchi, Jia, Qiong, Cheng, Tao, Zhu, Xiaofan, Leung, Anskar Yu-Hung, Yuan, Weiping, Jia, Haibo, Fang, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785739/
https://www.ncbi.nlm.nih.gov/pubmed/26961822
http://dx.doi.org/10.1186/s12920-016-0174-9

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