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Circulating micrornas associated with glycemic impairment and progression in Asian Indians

AIMS/HYPOTHESIS: Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeostasis and have not been previously studied in Asian Indians. We examined mic...

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Autores principales: Flowers, Elena, Gadgil, Meghana, Aouizerat, Bradley E., Kanaya, Alka M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785747/
https://www.ncbi.nlm.nih.gov/pubmed/26966540
http://dx.doi.org/10.1186/s40364-015-0047-y
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author Flowers, Elena
Gadgil, Meghana
Aouizerat, Bradley E.
Kanaya, Alka M.
author_facet Flowers, Elena
Gadgil, Meghana
Aouizerat, Bradley E.
Kanaya, Alka M.
author_sort Flowers, Elena
collection PubMed
description AIMS/HYPOTHESIS: Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeostasis and have not been previously studied in Asian Indians. We examined microRNA (miR) expression associated with glycemic impairment and progression in Asian Indians from the San Francisco Bay Area. We studied 128 Asian Indians age 45–84 years without known cardiovascular disease and not taking diabetes medications. Oral glucose tolerance tests were performed at baseline and after 2.5 years. We quantified circulating miRs from plasma collected during the enrollment visit using a flow cytometry-based assay. RESULTS: Glycemic impairment was present in 57 % (n = 73) at baseline. MiR-191 was positively associated with glycemic impairment (odds ratio (OR) 1.7 (95 % CI 1.2, 2.4), p < 0.01). The prevalence of glycemic progression after 2.5 years was 24 % (n = 23). Six miRs were negatively associated with glycemic progression: miR-122 (OR 0.5 (0.2, 0.8), p < 0.01), miR-15a (OR 0.6 (0.4, 0.9), p < 0.01), miR-197 (OR 0.6 (0.4, 0.9), p < 0.01), miR-320a (OR 0.6 (0.4, 0.9), p < 0.01), miR-423 (OR 0.6 (0.4, 0.9), p < 0.01), and miR-486 (OR 0.5 (0.3, 0.8), p < 0.01). Further multivariate adjustment did not attenuate these results. CONCLUSIONS/INTERPRETATION: This is the first study to investigate circulating miRs associated with glycemic status among this high-risk ethnic group. Individual miRs were significantly associated with both glycemic impairment and glycemic progression. Further studies are needed to determine whether miR (s) might be useful clinical biomarkers for incident T2D in the Asian Indian population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40364-015-0047-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-47857472016-03-11 Circulating micrornas associated with glycemic impairment and progression in Asian Indians Flowers, Elena Gadgil, Meghana Aouizerat, Bradley E. Kanaya, Alka M. Biomark Res Research AIMS/HYPOTHESIS: Asian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood. MicroRNAs are emerging as important mediators of glucose homeostasis and have not been previously studied in Asian Indians. We examined microRNA (miR) expression associated with glycemic impairment and progression in Asian Indians from the San Francisco Bay Area. We studied 128 Asian Indians age 45–84 years without known cardiovascular disease and not taking diabetes medications. Oral glucose tolerance tests were performed at baseline and after 2.5 years. We quantified circulating miRs from plasma collected during the enrollment visit using a flow cytometry-based assay. RESULTS: Glycemic impairment was present in 57 % (n = 73) at baseline. MiR-191 was positively associated with glycemic impairment (odds ratio (OR) 1.7 (95 % CI 1.2, 2.4), p < 0.01). The prevalence of glycemic progression after 2.5 years was 24 % (n = 23). Six miRs were negatively associated with glycemic progression: miR-122 (OR 0.5 (0.2, 0.8), p < 0.01), miR-15a (OR 0.6 (0.4, 0.9), p < 0.01), miR-197 (OR 0.6 (0.4, 0.9), p < 0.01), miR-320a (OR 0.6 (0.4, 0.9), p < 0.01), miR-423 (OR 0.6 (0.4, 0.9), p < 0.01), and miR-486 (OR 0.5 (0.3, 0.8), p < 0.01). Further multivariate adjustment did not attenuate these results. CONCLUSIONS/INTERPRETATION: This is the first study to investigate circulating miRs associated with glycemic status among this high-risk ethnic group. Individual miRs were significantly associated with both glycemic impairment and glycemic progression. Further studies are needed to determine whether miR (s) might be useful clinical biomarkers for incident T2D in the Asian Indian population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40364-015-0047-y) contains supplementary material, which is available to authorized users. BioMed Central 2015-10-13 /pmc/articles/PMC4785747/ /pubmed/26966540 http://dx.doi.org/10.1186/s40364-015-0047-y Text en © Flowers et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Flowers, Elena
Gadgil, Meghana
Aouizerat, Bradley E.
Kanaya, Alka M.
Circulating micrornas associated with glycemic impairment and progression in Asian Indians
title Circulating micrornas associated with glycemic impairment and progression in Asian Indians
title_full Circulating micrornas associated with glycemic impairment and progression in Asian Indians
title_fullStr Circulating micrornas associated with glycemic impairment and progression in Asian Indians
title_full_unstemmed Circulating micrornas associated with glycemic impairment and progression in Asian Indians
title_short Circulating micrornas associated with glycemic impairment and progression in Asian Indians
title_sort circulating micrornas associated with glycemic impairment and progression in asian indians
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785747/
https://www.ncbi.nlm.nih.gov/pubmed/26966540
http://dx.doi.org/10.1186/s40364-015-0047-y
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