Cargando…
Detecting uterine glandular lesions: Role of cervical cytology
BACKGROUND: The sensitivity of cervical cytology for detection of glandular lesions is reported to be low. We conducted this study to assess the diagnostic accuracy of cervical Papanicolaou (Pap) smears for uterine glandular lesions and to compare the diagnostic utility of conventional and liquid-ba...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785776/ https://www.ncbi.nlm.nih.gov/pubmed/27014363 http://dx.doi.org/10.4103/1742-6413.177156 |
_version_ | 1782420466871304192 |
---|---|
author | Bansal, Baneet Gupta, Parikshaa Gupta, Nalini Rajwanshi, Arvind Suri, Vanita |
author_facet | Bansal, Baneet Gupta, Parikshaa Gupta, Nalini Rajwanshi, Arvind Suri, Vanita |
author_sort | Bansal, Baneet |
collection | PubMed |
description | BACKGROUND: The sensitivity of cervical cytology for detection of glandular lesions is reported to be low. We conducted this study to assess the diagnostic accuracy of cervical Papanicolaou (Pap) smears for uterine glandular lesions and to compare the diagnostic utility of conventional and liquid-based cytology (LBC) smears for glandular lesions. MATERIALS AND METHODS: Archived histopathology records of all cases reported as endocervical and endometrial adenocarcinoma in the study period were identified and the available corresponding Pap smears (in preceding 1 year) were retrieved. In addition, the Pap smears reported as glandular cell abnormalities (GCA) during the same study period were retrieved. The overall prevalence of GCA, sensitivity, and specificity of Pap smears for the detection of GCA was calculated. The diagnostic accuracy of conventional and LBC smears for the diagnosis of GCA was also compared. RESULTS: The prevalence of GCA in our study was 0.32%. The overall specificity of Pap smears for the diagnosis of GCA was 60.8%, this was not significantly different between conventional and LBC smears (P = 0.4). The overall sensitivity of Pap smears for the detection of GCA was 41.8%; LBC smears had significantly better sensitivity as compared to conventional smears for the detection of endometrial as compared to endocervical adenocarcinoma (P < 0.05). CONCLUSIONS: The prevalence of GCA in Pap smears is low. The specificity of Pap smears, for diagnosis of GCA, was found to be moderate. However, the overall sensitivity of Pap smears for the detection of GCA was low, though better for LBC as compared to conventional smears. |
format | Online Article Text |
id | pubmed-4785776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47857762016-03-24 Detecting uterine glandular lesions: Role of cervical cytology Bansal, Baneet Gupta, Parikshaa Gupta, Nalini Rajwanshi, Arvind Suri, Vanita Cytojournal Research Article BACKGROUND: The sensitivity of cervical cytology for detection of glandular lesions is reported to be low. We conducted this study to assess the diagnostic accuracy of cervical Papanicolaou (Pap) smears for uterine glandular lesions and to compare the diagnostic utility of conventional and liquid-based cytology (LBC) smears for glandular lesions. MATERIALS AND METHODS: Archived histopathology records of all cases reported as endocervical and endometrial adenocarcinoma in the study period were identified and the available corresponding Pap smears (in preceding 1 year) were retrieved. In addition, the Pap smears reported as glandular cell abnormalities (GCA) during the same study period were retrieved. The overall prevalence of GCA, sensitivity, and specificity of Pap smears for the detection of GCA was calculated. The diagnostic accuracy of conventional and LBC smears for the diagnosis of GCA was also compared. RESULTS: The prevalence of GCA in our study was 0.32%. The overall specificity of Pap smears for the diagnosis of GCA was 60.8%, this was not significantly different between conventional and LBC smears (P = 0.4). The overall sensitivity of Pap smears for the detection of GCA was 41.8%; LBC smears had significantly better sensitivity as compared to conventional smears for the detection of endometrial as compared to endocervical adenocarcinoma (P < 0.05). CONCLUSIONS: The prevalence of GCA in Pap smears is low. The specificity of Pap smears, for diagnosis of GCA, was found to be moderate. However, the overall sensitivity of Pap smears for the detection of GCA was low, though better for LBC as compared to conventional smears. Medknow Publications & Media Pvt Ltd 2016-02-22 /pmc/articles/PMC4785776/ /pubmed/27014363 http://dx.doi.org/10.4103/1742-6413.177156 Text en Copyright: © 2016 Bansal, et al.; Licensee Cytopathology Foundation Inc. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Bansal, Baneet Gupta, Parikshaa Gupta, Nalini Rajwanshi, Arvind Suri, Vanita Detecting uterine glandular lesions: Role of cervical cytology |
title | Detecting uterine glandular lesions: Role of cervical cytology |
title_full | Detecting uterine glandular lesions: Role of cervical cytology |
title_fullStr | Detecting uterine glandular lesions: Role of cervical cytology |
title_full_unstemmed | Detecting uterine glandular lesions: Role of cervical cytology |
title_short | Detecting uterine glandular lesions: Role of cervical cytology |
title_sort | detecting uterine glandular lesions: role of cervical cytology |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785776/ https://www.ncbi.nlm.nih.gov/pubmed/27014363 http://dx.doi.org/10.4103/1742-6413.177156 |
work_keys_str_mv | AT bansalbaneet detectinguterineglandularlesionsroleofcervicalcytology AT guptaparikshaa detectinguterineglandularlesionsroleofcervicalcytology AT guptanalini detectinguterineglandularlesionsroleofcervicalcytology AT rajwanshiarvind detectinguterineglandularlesionsroleofcervicalcytology AT surivanita detectinguterineglandularlesionsroleofcervicalcytology |