The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity

The anaphase-promoting complex/cyclosome (APC/C) and the spindle assembly checkpoint (SAC), which inhibits the APC/C, are essential determinants of mitotic timing and faithful division of genetic material. Activation of the APC/C is known to depend on two APC/C-interacting E2 ubiquitin-conjugating e...

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Detalles Bibliográficos
Autores principales: Wild, Thomas, Larsen, Marie Sofie Yoo, Narita, Takeo, Schou, Julie, Nilsson, Jakob, Choudhary, Chunaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785794/
https://www.ncbi.nlm.nih.gov/pubmed/26904940
http://dx.doi.org/10.1016/j.celrep.2016.01.060

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