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Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD

Alzheimer disease (AD) is characterized by progressive memory loss, reduction in cognitive functions, and damage to the brain. The β-amyloid precursor protein can be sequentially cleaved by β- secretase and γ-secretase. Mutations in the presenilin1(PS1) are the most common cause of Familial Alzheime...

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Detalles Bibliográficos
Autores principales:	Li, Nuomin, Liu, Kefu, Qiu, Yunjie, Ren, Zehui, Dai, Rongji, Deng, Yulin, Qing, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786568/ https://www.ncbi.nlm.nih.gov/pubmed/27014058 http://dx.doi.org/10.3389/fnagi.2016.00051

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