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IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production

The immunoresponsive gene 1 (IRG1) protein has crucial functions in embryonic implantation and neurodegeneration. IRG1 promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species (ROS). The cytoprotective protein heme oxygenase-1 (HO-1), which generates e...

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Detalles Bibliográficos
Autores principales:	Jamal Uddin, Md, Joe, Yeonsoo, Kim, Seul-Ki, Oh Jeong, Sun, Ryter, Stefan W, Pae, Hyun-Ock, Chung, Hun Taeg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786624/ https://www.ncbi.nlm.nih.gov/pubmed/25640654 http://dx.doi.org/10.1038/cmi.2015.02

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