The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration

The high-mobility group box 1 (HMGB1) protein has a central role in immunological antitumour defense. Here we show that natural killer cell-derived HMGB1 directly eliminates cancer cells by triggering metabolic cell death. HMGB1 allosterically inhibits the tetrameric pyruvate kinase isoform M2, thus...

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Detalles Bibliográficos
Autores principales: Gdynia, Georg, Sauer, Sven W., Kopitz, Jürgen, Fuchs, Dominik, Duglova, Katarina, Ruppert, Thorsten, Miller, Matthias, Pahl, Jens, Cerwenka, Adelheid, Enders, Markus, Mairbäurl, Heimo, Kamiński, Marcin M., Penzel, Roland, Zhang, Christine, Fuller, Jonathan C., Wade, Rebecca C., Benner, Axel, Chang-Claude, Jenny, Brenner, Hermann, Hoffmeister, Michael, Zentgraf, Hanswalter, Schirmacher, Peter, Roth, Wilfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786644/
https://www.ncbi.nlm.nih.gov/pubmed/26948869
http://dx.doi.org/10.1038/ncomms10764

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