Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP(2)-PLC()

This article presents additional data regarding the study “The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium” [1]. The new data presented here show that short exposure of RPE cells to lipopolysaccharide (LPS) induces an early and transient activation of...

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Autores principales: Mateos, Melina V., Kamerbeek, Constanza B., Giusto, Norma M., Salvador, Gabriela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786752/
https://www.ncbi.nlm.nih.gov/pubmed/27006973
http://dx.doi.org/10.1016/j.dib.2016.02.057
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author Mateos, Melina V.
Kamerbeek, Constanza B.
Giusto, Norma M.
Salvador, Gabriela A.
author_facet Mateos, Melina V.
Kamerbeek, Constanza B.
Giusto, Norma M.
Salvador, Gabriela A.
author_sort Mateos, Melina V.
collection PubMed
description This article presents additional data regarding the study “The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium” [1]. The new data presented here show that short exposure of RPE cells to lipopolysaccharide (LPS) induces an early and transient activation of the extracellular signal-regulated kinase (ERK1/2). This early ERK1/2 activation is dependent on phosphatidylinositol bisphosphate-phospholipase C (PIP(2)-PLC). On the contrary, neither the phospholipase D 1 (PLD1) nor the PLD2 inhibition is able to modulate the early ERK1/2 activation induced by LPS in RPE cells.
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spelling pubmed-47867522016-03-22 Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP(2)-PLC() Mateos, Melina V. Kamerbeek, Constanza B. Giusto, Norma M. Salvador, Gabriela A. Data Brief Data Article This article presents additional data regarding the study “The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium” [1]. The new data presented here show that short exposure of RPE cells to lipopolysaccharide (LPS) induces an early and transient activation of the extracellular signal-regulated kinase (ERK1/2). This early ERK1/2 activation is dependent on phosphatidylinositol bisphosphate-phospholipase C (PIP(2)-PLC). On the contrary, neither the phospholipase D 1 (PLD1) nor the PLD2 inhibition is able to modulate the early ERK1/2 activation induced by LPS in RPE cells. Elsevier 2016-02-27 /pmc/articles/PMC4786752/ /pubmed/27006973 http://dx.doi.org/10.1016/j.dib.2016.02.057 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Mateos, Melina V.
Kamerbeek, Constanza B.
Giusto, Norma M.
Salvador, Gabriela A.
Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP(2)-PLC()
title Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP(2)-PLC()
title_full Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP(2)-PLC()
title_fullStr Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP(2)-PLC()
title_full_unstemmed Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP(2)-PLC()
title_short Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP(2)-PLC()
title_sort early lps-induced erk activation in retinal pigment epithelium cells is dependent on pip(2)-plc()
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786752/
https://www.ncbi.nlm.nih.gov/pubmed/27006973
http://dx.doi.org/10.1016/j.dib.2016.02.057
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