Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to energy supply and demand. Drugs that activate AMPK may be useful in the treatment of metabolic diseases including type 2 diabetes. We have determined the crystal structure...

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Detalles Bibliográficos
Autores principales: Langendorf, Christopher G., Ngoei, Kevin R. W., Scott, John W., Ling, Naomi X. Y., Issa, Sam M. A., Gorman, Michael A., Parker, Michael W., Sakamoto, Kei, Oakhill, Jonathan S., Kemp, Bruce E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786773/
https://www.ncbi.nlm.nih.gov/pubmed/26952388
http://dx.doi.org/10.1038/ncomms10912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786773/
https://www.ncbi.nlm.nih.gov/pubmed/26952388
http://dx.doi.org/10.1038/ncomms10912

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