An extended U2AF(65)–RNA-binding domain recognizes the 3′ splice site signal

How the essential pre-mRNA splicing factor U2AF(65) recognizes the polypyrimidine (Py) signals of the major class of 3′ splice sites in human gene transcripts remains incompletely understood. We determined four structures of an extended U2AF(65)–RNA-binding domain bound to Py-tract oligonucleotides...

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Detalles Bibliográficos
Autores principales: Agrawal, Anant A., Salsi, Enea, Chatrikhi, Rakesh, Henderson, Steven, Jenkins, Jermaine L., Green, Michael R., Ermolenko, Dmitri N., Kielkopf, Clara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786784/
https://www.ncbi.nlm.nih.gov/pubmed/26952537
http://dx.doi.org/10.1038/ncomms10950

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