Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells

Chloroquine (CQ), an anti-malarial drug, has immune-modulating activity and lysosomotropic activity. In this study, we investigated CQ sensitizes TRAIL-mediated apoptosis in human renal cancer Caki cells. Combination of CQ and TRAIL significantly induces apoptosis in human renal cancer Caki cells an...

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Detalles Bibliográficos
Autores principales: Park, Eun Jung, Min, Kyoung-jin, Choi, Kyeong Sook, Kubatka, Peter, Kruzliak, Peter, Kim, Dong Eun, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786792/
https://www.ncbi.nlm.nih.gov/pubmed/26964637
http://dx.doi.org/10.1038/srep22921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786792/
https://www.ncbi.nlm.nih.gov/pubmed/26964637
http://dx.doi.org/10.1038/srep22921

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