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Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786871/ https://www.ncbi.nlm.nih.gov/pubmed/26956414 http://dx.doi.org/10.1038/ncomms10933 |
| _version_ | 1782420617366077440 |
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| author | Berndt, Sonja I. Camp, Nicola J. Skibola, Christine F. Vijai, Joseph Wang, Zhaoming Gu, Jian Nieters, Alexandra Kelly, Rachel S. Smedby, Karin E. Monnereau, Alain Cozen, Wendy Cox, Angela Wang, Sophia S. Lan, Qing Teras, Lauren R. Machado, Moara Yeager, Meredith Brooks-Wilson, Angela R. Hartge, Patricia Purdue, Mark P. Birmann, Brenda M. Vajdic, Claire M. Cocco, Pierluigi Zhang, Yawei Giles, Graham G. Zeleniuch-Jacquotte, Anne Lawrence, Charles Montalvan, Rebecca Burdett, Laurie Hutchinson, Amy Ye, Yuanqing Call, Timothy G. Shanafelt, Tait D. Novak, Anne J. Kay, Neil E. Liebow, Mark Cunningham, Julie M. Allmer, Cristine Hjalgrim, Henrik Adami, Hans-Olov Melbye, Mads Glimelius, Bengt Chang, Ellen T. Glenn, Martha Curtin, Karen Cannon-Albright, Lisa A. Diver, W Ryan Link, Brian K. Weiner, George J. Conde, Lucia Bracci, Paige M. Riby, Jacques Arnett, Donna K. Zhi, Degui Leach, Justin M. Holly, Elizabeth A. Jackson, Rebecca D. Tinker, Lesley F. Benavente, Yolanda Sala, Núria Casabonne, Delphine Becker, Nikolaus Boffetta, Paolo Brennan, Paul Foretova, Lenka Maynadie, Marc McKay, James Staines, Anthony Chaffee, Kari G. Achenbach, Sara J. Vachon, Celine M. Goldin, Lynn R. Strom, Sara S. Leis, Jose F. Weinberg, J. Brice Caporaso, Neil E. Norman, Aaron D. De Roos, Anneclaire J. Morton, Lindsay M. Severson, Richard K. Riboli, Elio Vineis, Paolo Kaaks, Rudolph Masala, Giovanna Weiderpass, Elisabete Chirlaque, María- Dolores Vermeulen, Roel C. H. Travis, Ruth C. Southey, Melissa C. Milne, Roger L. Albanes, Demetrius Virtamo, Jarmo Weinstein, Stephanie Clavel, Jacqueline Zheng, Tongzhang Holford, Theodore R. Villano, Danylo J. Maria, Ann Spinelli, John J. Gascoyne, Randy D. Connors, Joseph M. Bertrand, Kimberly A. Giovannucci, Edward Kraft, Peter Kricker, Anne Turner, Jenny Ennas, Maria Grazia Ferri, Giovanni M. Miligi, Lucia Liang, Liming Ma, Baoshan Huang, Jinyan Crouch, Simon Park, Ju-Hyun Chatterjee, Nilanjan North, Kari E. Snowden, John A. Wright, Josh Fraumeni, Joseph F. Offit, Kenneth Wu, Xifeng de Sanjose, Silvia Cerhan, James R. Chanock, Stephen J. Rothman, Nathaniel Slager, Susan L. |
| author_facet | Berndt, Sonja I. Camp, Nicola J. Skibola, Christine F. Vijai, Joseph Wang, Zhaoming Gu, Jian Nieters, Alexandra Kelly, Rachel S. Smedby, Karin E. Monnereau, Alain Cozen, Wendy Cox, Angela Wang, Sophia S. Lan, Qing Teras, Lauren R. Machado, Moara Yeager, Meredith Brooks-Wilson, Angela R. Hartge, Patricia Purdue, Mark P. Birmann, Brenda M. Vajdic, Claire M. Cocco, Pierluigi Zhang, Yawei Giles, Graham G. Zeleniuch-Jacquotte, Anne Lawrence, Charles Montalvan, Rebecca Burdett, Laurie Hutchinson, Amy Ye, Yuanqing Call, Timothy G. Shanafelt, Tait D. Novak, Anne J. Kay, Neil E. Liebow, Mark Cunningham, Julie M. Allmer, Cristine Hjalgrim, Henrik Adami, Hans-Olov Melbye, Mads Glimelius, Bengt Chang, Ellen T. Glenn, Martha Curtin, Karen Cannon-Albright, Lisa A. Diver, W Ryan Link, Brian K. Weiner, George J. Conde, Lucia Bracci, Paige M. Riby, Jacques Arnett, Donna K. Zhi, Degui Leach, Justin M. Holly, Elizabeth A. Jackson, Rebecca D. Tinker, Lesley F. Benavente, Yolanda Sala, Núria Casabonne, Delphine Becker, Nikolaus Boffetta, Paolo Brennan, Paul Foretova, Lenka Maynadie, Marc McKay, James Staines, Anthony Chaffee, Kari G. Achenbach, Sara J. Vachon, Celine M. Goldin, Lynn R. Strom, Sara S. Leis, Jose F. Weinberg, J. Brice Caporaso, Neil E. Norman, Aaron D. De Roos, Anneclaire J. Morton, Lindsay M. Severson, Richard K. Riboli, Elio Vineis, Paolo Kaaks, Rudolph Masala, Giovanna Weiderpass, Elisabete Chirlaque, María- Dolores Vermeulen, Roel C. H. Travis, Ruth C. Southey, Melissa C. Milne, Roger L. Albanes, Demetrius Virtamo, Jarmo Weinstein, Stephanie Clavel, Jacqueline Zheng, Tongzhang Holford, Theodore R. Villano, Danylo J. Maria, Ann Spinelli, John J. Gascoyne, Randy D. Connors, Joseph M. Bertrand, Kimberly A. Giovannucci, Edward Kraft, Peter Kricker, Anne Turner, Jenny Ennas, Maria Grazia Ferri, Giovanni M. Miligi, Lucia Liang, Liming Ma, Baoshan Huang, Jinyan Crouch, Simon Park, Ju-Hyun Chatterjee, Nilanjan North, Kari E. Snowden, John A. Wright, Josh Fraumeni, Joseph F. Offit, Kenneth Wu, Xifeng de Sanjose, Silvia Cerhan, James R. Chanock, Stephen J. Rothman, Nathaniel Slager, Susan L. |
| author_sort | Berndt, Sonja I. |
| collection | PubMed |
| description | Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(−11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(−8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(−8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(−11)) in the combined analysis. We find suggestive evidence (P<5 × 10(−7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(−8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(−7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. |
| format | Online Article Text |
| id | pubmed-4786871 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47868712016-03-16 Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia Berndt, Sonja I. Camp, Nicola J. Skibola, Christine F. Vijai, Joseph Wang, Zhaoming Gu, Jian Nieters, Alexandra Kelly, Rachel S. Smedby, Karin E. Monnereau, Alain Cozen, Wendy Cox, Angela Wang, Sophia S. Lan, Qing Teras, Lauren R. Machado, Moara Yeager, Meredith Brooks-Wilson, Angela R. Hartge, Patricia Purdue, Mark P. Birmann, Brenda M. Vajdic, Claire M. Cocco, Pierluigi Zhang, Yawei Giles, Graham G. Zeleniuch-Jacquotte, Anne Lawrence, Charles Montalvan, Rebecca Burdett, Laurie Hutchinson, Amy Ye, Yuanqing Call, Timothy G. Shanafelt, Tait D. Novak, Anne J. Kay, Neil E. Liebow, Mark Cunningham, Julie M. Allmer, Cristine Hjalgrim, Henrik Adami, Hans-Olov Melbye, Mads Glimelius, Bengt Chang, Ellen T. Glenn, Martha Curtin, Karen Cannon-Albright, Lisa A. Diver, W Ryan Link, Brian K. Weiner, George J. Conde, Lucia Bracci, Paige M. Riby, Jacques Arnett, Donna K. Zhi, Degui Leach, Justin M. Holly, Elizabeth A. Jackson, Rebecca D. Tinker, Lesley F. Benavente, Yolanda Sala, Núria Casabonne, Delphine Becker, Nikolaus Boffetta, Paolo Brennan, Paul Foretova, Lenka Maynadie, Marc McKay, James Staines, Anthony Chaffee, Kari G. Achenbach, Sara J. Vachon, Celine M. Goldin, Lynn R. Strom, Sara S. Leis, Jose F. Weinberg, J. Brice Caporaso, Neil E. Norman, Aaron D. De Roos, Anneclaire J. Morton, Lindsay M. Severson, Richard K. Riboli, Elio Vineis, Paolo Kaaks, Rudolph Masala, Giovanna Weiderpass, Elisabete Chirlaque, María- Dolores Vermeulen, Roel C. H. Travis, Ruth C. Southey, Melissa C. Milne, Roger L. Albanes, Demetrius Virtamo, Jarmo Weinstein, Stephanie Clavel, Jacqueline Zheng, Tongzhang Holford, Theodore R. Villano, Danylo J. Maria, Ann Spinelli, John J. Gascoyne, Randy D. Connors, Joseph M. Bertrand, Kimberly A. Giovannucci, Edward Kraft, Peter Kricker, Anne Turner, Jenny Ennas, Maria Grazia Ferri, Giovanni M. Miligi, Lucia Liang, Liming Ma, Baoshan Huang, Jinyan Crouch, Simon Park, Ju-Hyun Chatterjee, Nilanjan North, Kari E. Snowden, John A. Wright, Josh Fraumeni, Joseph F. Offit, Kenneth Wu, Xifeng de Sanjose, Silvia Cerhan, James R. Chanock, Stephen J. Rothman, Nathaniel Slager, Susan L. Nat Commun Article Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(−11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(−8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(−8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(−11)) in the combined analysis. We find suggestive evidence (P<5 × 10(−7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(−8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(−7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. Nature Publishing Group 2016-03-09 /pmc/articles/PMC4786871/ /pubmed/26956414 http://dx.doi.org/10.1038/ncomms10933 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Berndt, Sonja I. Camp, Nicola J. Skibola, Christine F. Vijai, Joseph Wang, Zhaoming Gu, Jian Nieters, Alexandra Kelly, Rachel S. Smedby, Karin E. Monnereau, Alain Cozen, Wendy Cox, Angela Wang, Sophia S. Lan, Qing Teras, Lauren R. Machado, Moara Yeager, Meredith Brooks-Wilson, Angela R. Hartge, Patricia Purdue, Mark P. Birmann, Brenda M. Vajdic, Claire M. Cocco, Pierluigi Zhang, Yawei Giles, Graham G. Zeleniuch-Jacquotte, Anne Lawrence, Charles Montalvan, Rebecca Burdett, Laurie Hutchinson, Amy Ye, Yuanqing Call, Timothy G. Shanafelt, Tait D. Novak, Anne J. Kay, Neil E. Liebow, Mark Cunningham, Julie M. Allmer, Cristine Hjalgrim, Henrik Adami, Hans-Olov Melbye, Mads Glimelius, Bengt Chang, Ellen T. Glenn, Martha Curtin, Karen Cannon-Albright, Lisa A. Diver, W Ryan Link, Brian K. Weiner, George J. Conde, Lucia Bracci, Paige M. Riby, Jacques Arnett, Donna K. Zhi, Degui Leach, Justin M. Holly, Elizabeth A. Jackson, Rebecca D. Tinker, Lesley F. Benavente, Yolanda Sala, Núria Casabonne, Delphine Becker, Nikolaus Boffetta, Paolo Brennan, Paul Foretova, Lenka Maynadie, Marc McKay, James Staines, Anthony Chaffee, Kari G. Achenbach, Sara J. Vachon, Celine M. Goldin, Lynn R. Strom, Sara S. Leis, Jose F. Weinberg, J. Brice Caporaso, Neil E. Norman, Aaron D. De Roos, Anneclaire J. Morton, Lindsay M. Severson, Richard K. Riboli, Elio Vineis, Paolo Kaaks, Rudolph Masala, Giovanna Weiderpass, Elisabete Chirlaque, María- Dolores Vermeulen, Roel C. H. Travis, Ruth C. Southey, Melissa C. Milne, Roger L. Albanes, Demetrius Virtamo, Jarmo Weinstein, Stephanie Clavel, Jacqueline Zheng, Tongzhang Holford, Theodore R. Villano, Danylo J. Maria, Ann Spinelli, John J. Gascoyne, Randy D. Connors, Joseph M. Bertrand, Kimberly A. Giovannucci, Edward Kraft, Peter Kricker, Anne Turner, Jenny Ennas, Maria Grazia Ferri, Giovanni M. Miligi, Lucia Liang, Liming Ma, Baoshan Huang, Jinyan Crouch, Simon Park, Ju-Hyun Chatterjee, Nilanjan North, Kari E. Snowden, John A. Wright, Josh Fraumeni, Joseph F. Offit, Kenneth Wu, Xifeng de Sanjose, Silvia Cerhan, James R. Chanock, Stephen J. Rothman, Nathaniel Slager, Susan L. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title | Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_full | Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_fullStr | Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_full_unstemmed | Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_short | Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_sort | meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786871/ https://www.ncbi.nlm.nih.gov/pubmed/26956414 http://dx.doi.org/10.1038/ncomms10933 |
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metaanalysisofgenomewideassociationstudiesdiscoversmultiplelociforchroniclymphocyticleukemia |