Cargando…

MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration

Mitochondrial Ca(2+) uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1). However, the physiological and pathological role of MICU1 remains unclear. Here we show that MICU1 is vital for adaptation to post...

Descripción completa

Detalles Bibliográficos
Autores principales:	Antony, Anil Noronha, Paillard, Melanie, Moffat, Cynthia, Juskeviciute, Egle, Correnti, Jason, Bolon, Brad, Rubin, Emanuel, Csordás, György, Seifert, Erin L., Hoek, Jan B., Hajnóczky, György
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786880/ https://www.ncbi.nlm.nih.gov/pubmed/26956930 http://dx.doi.org/10.1038/ncomms10955

Ejemplares similares

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca(2+) Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU
por: Paillard, Melanie, et al.
Publicado: (2017)

Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients
por: Singh, Raghavendra, et al.
Publicado: (2022)

MICU1 occludes the mitochondrial calcium uniporter in divalent-free conditions
por: Rodríguez-Prados, Macarena, et al.
Publicado: (2023)

Dysregulation of Mitochondrial Ca(2+) Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1
por: Debattisti, Valentina, et al.
Publicado: (2019)

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling
por: Roy Chowdhury, Anindya, et al.
Publicado: (2020)

Fuel oxidation under the control of mitochondrial shape and dynamics
por: Seifert, Erin L, et al.
Publicado: (2023)

Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics()
por: Bhosale, Gauri, et al.
Publicado: (2017)

Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism
por: Naghdi, Shamim, et al.
Publicado: (2018)

MICU1 and MICU2 Play an Essential Role in Mitochondrial Ca(2+) Uptake, Growth, and Infectivity of the Human Pathogen Trypanosoma cruzi
por: Bertolini, Mayara S., et al.
Publicado: (2019)

Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat
por: Juskeviciute, Egle, et al.
Publicado: (2008)

Dysregulation of miR-21-associated miRNA regulatory networks by chronic ethanol consumption impairs liver regeneration
por: Parrish, Austin, et al.
Publicado: (2021)

A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration
por: Kuttippurathu, Lakshmi, et al.
Publicado: (2016)

Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2
por: Wang, Chongyuan, et al.
Publicado: (2020)

Structure of the MICU1–MICU2 heterodimer provides insights into the gatekeeping threshold shift
por: Park, Jongseo, et al.
Publicado: (2020)

Structural and functional features and significance of the physical linkage between ER and mitochondria
por: Csordás, György, et al.
Publicado: (2006)

MCUR1 is an Essential Component of Mitochondrial Ca(2+) Uptake that Regulates Cellular Metabolism
por: Mallilankaraman, Karthik, et al.
Publicado: (2012)

MICU1-dependent mitochondrial calcium uptake regulates lung alveolar type 2 cell plasticity and lung regeneration
por: Ali, Mir, et al.
Publicado: (2022)

Trans-mitochondrial coordination of cristae at regulated membrane junctions
por: Picard, Martin, et al.
Publicado: (2015)

Capture at the ER-mitochondrial contacts licenses IP(3) receptors to stimulate local Ca(2+) transfer and oxidative metabolism
por: Katona, Máté, et al.
Publicado: (2022)

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake
por: Perocchi, Fabiana, et al.
Publicado: (2010)

miR‐181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart
por: Banavath, Hemanth N., et al.
Publicado: (2019)

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling
por: Plovanich, Molly, et al.
Publicado: (2013)

MICU1 and MICU2 Finely Tune the Mitochondrial Ca(2+) Uniporter by Exerting Opposite Effects on MCU Activity
por: Patron, Maria, et al.
Publicado: (2014)

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
por: Madesh, Muniswamy, et al.
Publicado: (2001)

Expression and preliminary characterization of human MICU2
por: Li, Dan, et al.
Publicado: (2016)

MICU1- Related Myopathy with Extrapyramidal Signs
por: Mukherjee, Debaleena, et al.
Publicado: (2023)

The Function of Mitochondrial Calcium Uniporter at the Whole-Cell and Single Mitochondrion Levels in WT, MICU1 KO, and MICU2 KO Cells
por: Shah, Syed Islamuddin, et al.
Publicado: (2020)

Different Sensitivity of Control and MICU1- and MICU2-Ablated Trypanosoma cruzi Mitochondrial Calcium Uniporter Complex to Ruthenium-Based Inhibitors
por: Bertolini, Mayara S., et al.
Publicado: (2020)

MICU1 drives glycolysis and chemoresistance in ovarian cancer
por: Chakraborty, Prabir K., et al.
Publicado: (2017)

Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit
por: Yi, Muqing, et al.
Publicado: (2004)

Mitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling
por: Eisner, Verónica, et al.
Publicado: (2014)

Just how many holes…?
por: Csordas, Gyorgy, et al.
Publicado: (2020)

SEPSIS LEADS TO IMPAIRED MITOCHONDRIAL CALCIUM UPTAKE AND SKELETAL MUSCLE WEAKNESS BY REDUCING THE MICU1:MCU PROTEIN RATIO
por: Li, Xuexin, et al.
Publicado: (2023)

OPA1 Modulates Mitochondrial Ca(2+) Uptake Through ER-Mitochondria Coupling
por: Cartes-Saavedra, Benjamín, et al.
Publicado: (2022)

Effects of MICU1-Mediated Mitochondrial Calcium Uptake on Energy Metabolism and Quality of Vitrified-Thawed Mouse Metaphase II Oocytes
por: Lan, Tianyang, et al.
Publicado: (2022)

Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood
por: Lewis-Smith, David, et al.
Publicado: (2016)

Parkin-dependent regulation of the MCU complex component MICU1
por: Matteucci, Alessandra, et al.
Publicado: (2018)

Structure of intact human MCU supercomplex with the auxiliary MICU subunits
por: Zhuo, Wei, et al.
Publicado: (2020)

The mechanism of MICU-dependent gating of the mitochondrial Ca(2+)uniporter
por: Garg, Vivek, et al.
Publicado: (2021)

Autosomal Recessive Mitochondrial Myopathy due to MICU-1 Variants
por: Finsterer, Josef
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_uq1cpfvde12sk7h4vu33u1plqn