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Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

The rapid advancement in targeted genome editing using engineered nucleases such as ZFNs, TALENs, and CRISPR/Cas9 systems has resulted in a suite of powerful methods that allows researchers to target any genomic locus of interest. A complementary set of design tools has been developed to aid researc...

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Detalles Bibliográficos
Autores principales:	Lee, Ciaran M, Cradick, Thomas J, Fine, Eli J, Bao, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786925/ https://www.ncbi.nlm.nih.gov/pubmed/26750397 http://dx.doi.org/10.1038/mt.2016.1

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