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Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke

OBJECTIVE: Resting metabolic rate (RMR) is the component of energy expenditure that explains the largest proportion of total daily energy requirements. Since RMR is determined largely by fat-free mass and a low RMR predicts weight gain in healthy adults, identifying the role of muscle atrophy follow...

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Autores principales: Serra, Monica C, Hafer-Macko, Charlene E, Ryan, Alice S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786940/
https://www.ncbi.nlm.nih.gov/pubmed/26973796
http://dx.doi.org/10.4172/2155-9562.1000341
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author Serra, Monica C
Hafer-Macko, Charlene E
Ryan, Alice S
author_facet Serra, Monica C
Hafer-Macko, Charlene E
Ryan, Alice S
author_sort Serra, Monica C
collection PubMed
description OBJECTIVE: Resting metabolic rate (RMR) is the component of energy expenditure that explains the largest proportion of total daily energy requirements. Since RMR is determined largely by fat-free mass and a low RMR predicts weight gain in healthy adults, identifying the role of muscle atrophy following stroke on RMR may help identify ways to mitigate the development of obesity post-stroke. METHODS: Thirty-nine stroke survivors with chronic hemiparesis (mean ± SEM: age: 61 ± 1 years, latency from stroke: 107 ± 40 months, BMI: 31 ± 3 kg/m2) underwent DXA scans for measurement of body composition, including total, paretic, and non-paretic leg lean mass and fasted, 30-min indirect calorimetry for measurement of RMR. RESULT: Predicted RMR was calculated by the Mifflin-St Jeor equation, which considers weight, height, and age for both men and women. RMR was 14% lower than predicted (1438 ± 45 vs. 1669 ± 38 kcals/24 hrs; P<0.01). Total (r=0.73, P<0.01), paretic (r=0.72, P<0.01) and non-paretic (r=0.67, P<0.01) leg lean mass predicted RMR. CONCLUSION: These data indicate that muscle atrophy post stroke may lead to a reduced RMR. This substantiates the need to attenuate the loss of lean mass after a stroke to prevent declines in RMR and possible weight gain common post-stroke.
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spelling pubmed-47869402016-03-11 Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke Serra, Monica C Hafer-Macko, Charlene E Ryan, Alice S J Neurol Neurophysiol Article OBJECTIVE: Resting metabolic rate (RMR) is the component of energy expenditure that explains the largest proportion of total daily energy requirements. Since RMR is determined largely by fat-free mass and a low RMR predicts weight gain in healthy adults, identifying the role of muscle atrophy following stroke on RMR may help identify ways to mitigate the development of obesity post-stroke. METHODS: Thirty-nine stroke survivors with chronic hemiparesis (mean ± SEM: age: 61 ± 1 years, latency from stroke: 107 ± 40 months, BMI: 31 ± 3 kg/m2) underwent DXA scans for measurement of body composition, including total, paretic, and non-paretic leg lean mass and fasted, 30-min indirect calorimetry for measurement of RMR. RESULT: Predicted RMR was calculated by the Mifflin-St Jeor equation, which considers weight, height, and age for both men and women. RMR was 14% lower than predicted (1438 ± 45 vs. 1669 ± 38 kcals/24 hrs; P<0.01). Total (r=0.73, P<0.01), paretic (r=0.72, P<0.01) and non-paretic (r=0.67, P<0.01) leg lean mass predicted RMR. CONCLUSION: These data indicate that muscle atrophy post stroke may lead to a reduced RMR. This substantiates the need to attenuate the loss of lean mass after a stroke to prevent declines in RMR and possible weight gain common post-stroke. 2015-12-22 /pmc/articles/PMC4786940/ /pubmed/26973796 http://dx.doi.org/10.4172/2155-9562.1000341 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Serra, Monica C
Hafer-Macko, Charlene E
Ryan, Alice S
Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke
title Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke
title_full Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke
title_fullStr Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke
title_full_unstemmed Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke
title_short Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke
title_sort reduced resting metabolic rate in adults with hemiparetic chronic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786940/
https://www.ncbi.nlm.nih.gov/pubmed/26973796
http://dx.doi.org/10.4172/2155-9562.1000341
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