Tuning the nitric oxide release from CPO-27 MOFs

Nitric oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage...

Descripción completa

Detalles Bibliográficos
Autores principales: Cattaneo, Damiano, Warrender, Stewart J., Duncan, Morven J., Kelsall, Christopher J., Doherty, Mary K., Whitfield, Phillip D., Megson, Ian L., Morris, Russell E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786954/
https://www.ncbi.nlm.nih.gov/pubmed/27019705
http://dx.doi.org/10.1039/c5ra24023a
_version_ 1782420627691405312
author Cattaneo, Damiano
Warrender, Stewart J.
Duncan, Morven J.
Kelsall, Christopher J.
Doherty, Mary K.
Whitfield, Phillip D.
Megson, Ian L.
Morris, Russell E.
author_facet Cattaneo, Damiano
Warrender, Stewart J.
Duncan, Morven J.
Kelsall, Christopher J.
Doherty, Mary K.
Whitfield, Phillip D.
Megson, Ian L.
Morris, Russell E.
author_sort Cattaneo, Damiano
collection PubMed
description Nitric oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that the NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications.
format Online
Article
Text
id pubmed-4786954
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-47869542016-03-24 Tuning the nitric oxide release from CPO-27 MOFs Cattaneo, Damiano Warrender, Stewart J. Duncan, Morven J. Kelsall, Christopher J. Doherty, Mary K. Whitfield, Phillip D. Megson, Ian L. Morris, Russell E. RSC Adv Chemistry Nitric oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that the NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications. Royal Society of Chemistry 2016-02-13 2016-02-03 /pmc/articles/PMC4786954/ /pubmed/27019705 http://dx.doi.org/10.1039/c5ra24023a Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Cattaneo, Damiano
Warrender, Stewart J.
Duncan, Morven J.
Kelsall, Christopher J.
Doherty, Mary K.
Whitfield, Phillip D.
Megson, Ian L.
Morris, Russell E.
Tuning the nitric oxide release from CPO-27 MOFs
title Tuning the nitric oxide release from CPO-27 MOFs
title_full Tuning the nitric oxide release from CPO-27 MOFs
title_fullStr Tuning the nitric oxide release from CPO-27 MOFs
title_full_unstemmed Tuning the nitric oxide release from CPO-27 MOFs
title_short Tuning the nitric oxide release from CPO-27 MOFs
title_sort tuning the nitric oxide release from cpo-27 mofs
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786954/
https://www.ncbi.nlm.nih.gov/pubmed/27019705
http://dx.doi.org/10.1039/c5ra24023a
work_keys_str_mv AT cattaneodamiano tuningthenitricoxidereleasefromcpo27mofs
AT warrenderstewartj tuningthenitricoxidereleasefromcpo27mofs
AT duncanmorvenj tuningthenitricoxidereleasefromcpo27mofs
AT kelsallchristopherj tuningthenitricoxidereleasefromcpo27mofs
AT dohertymaryk tuningthenitricoxidereleasefromcpo27mofs
AT whitfieldphillipd tuningthenitricoxidereleasefromcpo27mofs
AT megsonianl tuningthenitricoxidereleasefromcpo27mofs
AT morrisrusselle tuningthenitricoxidereleasefromcpo27mofs

Ejemplares similares