Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))–H bonds

The first nickel catalyzed deprotonative cross coupling between C(sp(3))–H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmeth...

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Detalles Bibliográficos
Autores principales: Fernández-Salas, José A., Marelli, Enrico, Nolan, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786957/
https://www.ncbi.nlm.nih.gov/pubmed/27019690
http://dx.doi.org/10.1039/c5sc01589h
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author Fernández-Salas, José A.
Marelli, Enrico
Nolan, Steven P.
author_facet Fernández-Salas, José A.
Marelli, Enrico
Nolan, Steven P.
author_sort Fernández-Salas, José A.
collection PubMed
description The first nickel catalyzed deprotonative cross coupling between C(sp(3))–H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds.
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spelling pubmed-47869572016-03-24 Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))–H bonds Fernández-Salas, José A. Marelli, Enrico Nolan, Steven P. Chem Sci Chemistry The first nickel catalyzed deprotonative cross coupling between C(sp(3))–H bonds and aryl chlorides is reported, allowing the challenging arylation of benzylimines in the absence of directing group or stoichiometric metal activation. This methodology represents a convenient access to the (diarylmethyl)amine moiety, which is widespread in pharmaceutically relevant compounds. Royal Society of Chemistry 2015-08-01 2015-06-12 /pmc/articles/PMC4786957/ /pubmed/27019690 http://dx.doi.org/10.1039/c5sc01589h Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Fernández-Salas, José A.
Marelli, Enrico
Nolan, Steven P.
Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))–H bonds
title Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))–H bonds
title_full Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))–H bonds
title_fullStr Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))–H bonds
title_full_unstemmed Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))–H bonds
title_short Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(sp(3))–H bonds
title_sort synthesis of (diarylmethyl)amines using ni-catalyzed arylation of c(sp(3))–h bonds
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786957/
https://www.ncbi.nlm.nih.gov/pubmed/27019690
http://dx.doi.org/10.1039/c5sc01589h
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