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Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient

AIM: The aim was to develop a novel excipient from Pleurotus tuber-regium (PT)-cornstarch (CS) mixture and evaluate its multifunctional characteristics in tablet formulation. MATERIALS AND METHODS: Composites were generated from dephytochemicalized PT and CS combined at 1:1 to 4:1 ratios and pregela...

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Autores principales: Okoye, Ebere I, Onyekweli, Anthony O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787058/
https://www.ncbi.nlm.nih.gov/pubmed/27014615
http://dx.doi.org/10.4103/2230-973X.176461
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author Okoye, Ebere I
Onyekweli, Anthony O
author_facet Okoye, Ebere I
Onyekweli, Anthony O
author_sort Okoye, Ebere I
collection PubMed
description AIM: The aim was to develop a novel excipient from Pleurotus tuber-regium (PT)-cornstarch (CS) mixture and evaluate its multifunctional characteristics in tablet formulation. MATERIALS AND METHODS: Composites were generated from dephytochemicalized PT and CS combined at 1:1 to 4:1 ratios and pregelatinized in a hot water bath at 65°C ± 2°C for 5 min. The paste was dried, pulverized, and screened through 150-μm sieve. PT-CS physical mixtures were prepared and their characteristics/functionalities in tableting chloroquine were compared to those of composites and microcrystalline cellulose (Avicel(®)). RESULTS: PT ash value was 0.40 ± 0.09% and heavy metal contents were below official limits. PT's differential scanning calorimetric (DSC) thermogram depicted broad melting peak at 329.5°C; this peak was attenuated by the presence of CS. Fourier transform infrared (FTIR) spectra predicted compatibility between PT and CS. Composites consolidated better and also flowed better than physical mixtures and Avicel(®). Increasing PT content enhanced the excipients’ swellabilities, and composites possessed significantly (P < 0.05) better swelling indices than Avicel(®). The composites underwent fragmentation before plastic deformation with yield pressures significantly (P < 0.05) higher than those of the physical mixtures, which exhibited only plastic deformation. The mechanical properties of chloroquine tablets were acceptable, with the 1:4 (PT:CS) imparting the best properties. Mean disintegration times for the commercial comparator and Avicel(®) -containing tablets were significantly higher (P < 0.05) than those of composites. Drug release from tablets formulated with composites were similar to the commercial comparator, but significantly higher (P < 0.05) than those of Avicel(®). CONCLUSION: The novel composites are excellent multifunctional excipients, the best (PT:CS 1:4) one showcasing potentially better mechanical functionality than Avicel(®), a popular multifunctional excipient.
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spelling pubmed-47870582016-03-24 Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient Okoye, Ebere I Onyekweli, Anthony O Int J Pharm Investig Original Research Article AIM: The aim was to develop a novel excipient from Pleurotus tuber-regium (PT)-cornstarch (CS) mixture and evaluate its multifunctional characteristics in tablet formulation. MATERIALS AND METHODS: Composites were generated from dephytochemicalized PT and CS combined at 1:1 to 4:1 ratios and pregelatinized in a hot water bath at 65°C ± 2°C for 5 min. The paste was dried, pulverized, and screened through 150-μm sieve. PT-CS physical mixtures were prepared and their characteristics/functionalities in tableting chloroquine were compared to those of composites and microcrystalline cellulose (Avicel(®)). RESULTS: PT ash value was 0.40 ± 0.09% and heavy metal contents were below official limits. PT's differential scanning calorimetric (DSC) thermogram depicted broad melting peak at 329.5°C; this peak was attenuated by the presence of CS. Fourier transform infrared (FTIR) spectra predicted compatibility between PT and CS. Composites consolidated better and also flowed better than physical mixtures and Avicel(®). Increasing PT content enhanced the excipients’ swellabilities, and composites possessed significantly (P < 0.05) better swelling indices than Avicel(®). The composites underwent fragmentation before plastic deformation with yield pressures significantly (P < 0.05) higher than those of the physical mixtures, which exhibited only plastic deformation. The mechanical properties of chloroquine tablets were acceptable, with the 1:4 (PT:CS) imparting the best properties. Mean disintegration times for the commercial comparator and Avicel(®) -containing tablets were significantly higher (P < 0.05) than those of composites. Drug release from tablets formulated with composites were similar to the commercial comparator, but significantly higher (P < 0.05) than those of Avicel(®). CONCLUSION: The novel composites are excellent multifunctional excipients, the best (PT:CS 1:4) one showcasing potentially better mechanical functionality than Avicel(®), a popular multifunctional excipient. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4787058/ /pubmed/27014615 http://dx.doi.org/10.4103/2230-973X.176461 Text en Copyright: © International Journal of Pharmaceutical Investigation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Research Article
Okoye, Ebere I
Onyekweli, Anthony O
Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient
title Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient
title_full Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient
title_fullStr Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient
title_full_unstemmed Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient
title_short Development and evaluation of Pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient
title_sort development and evaluation of pleurotus tuber-regium-cornstarch composite as a direct compression multifunctional excipient
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787058/
https://www.ncbi.nlm.nih.gov/pubmed/27014615
http://dx.doi.org/10.4103/2230-973X.176461
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