Cargando…

Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma

BACKGROUND: In traditional Chinese medicine, Atractylodis rhizoma is the dried rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz. After being processed, the dryness of A. rhizoma decreased, and the function of tonifying spleen increased. Therefore, the processed A. rh...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao-Wen, Chang, Chen-Xi, Xu, Yu-Qiang, Liu, Cai, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787342/
https://www.ncbi.nlm.nih.gov/pubmed/27019565
http://dx.doi.org/10.4103/0973-1296.176062
_version_ 1782420674194702336
author Xiao-Wen, Chang
Chen-Xi, Xu
Yu-Qiang, Liu
Cai, Qian
author_facet Xiao-Wen, Chang
Chen-Xi, Xu
Yu-Qiang, Liu
Cai, Qian
author_sort Xiao-Wen, Chang
collection PubMed
description BACKGROUND: In traditional Chinese medicine, Atractylodis rhizoma is the dried rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz. After being processed, the dryness of A. rhizoma decreased, and the function of tonifying spleen increased. Therefore, the processed A. rhizoma is the best choice of clinical application. As the main active components, polyethylene alkynes exhibits various desirable pharmacological effects including anti-inflammatory, anti-bacterial and anti-arrhythmia activity. However, there is no report on the pharmacokinetic comparisons of atractylodin, one of polyethylene alkynes, in bio-samples after oral administration of crude and processed A. rhizoma until now. The in vivo study of active components of A. rhizoma would be necessary and helpful for clinical application and clarification of processing principle. OBJECTIVE: To compare the pharmacokinetic parameters of atractylodin after oral administration of crude and processed A. rhizoma, and clarify the processing principle of A. rhizoma. MATERIALS AND METHODS: Plasma concentrations of atractylodin in rats were determined by reversed-phase high-performance liquid chromatogram and the main pharmacokinetic parameters were estimated with Drug and Statistics 2.0 Software Package (Chinese Pharmacological Society, Shanghai, China). RESULTS: The AUC(0−t), AUC(0→∞), T(max), and C(max) of processed A. rhizoma were increased significantly (P < 0.05) compared with that in crude A. rhizoma after using Student's t-test. CONCLUSIONS: Processing A. rhizoma with wheat bran by stir-frying can promote and accelerate the absorption of atractylodin. SUMMARY: In this paper, a RP-HPLC method with UV detection for quantification of atractylodin (a main active component in Atractylodis Rhizoma) in rat plasma has been developed and applied to a preliminary pharmacokinetic study of atractylodin after oral administration of crude and processed Atractylodis Rhizoma respectively. The result indicates that processing Atractylodis Rhizoma with wheat-bran can promote and accelerate the absorption of atractylodin.
format Online
Article
Text
id pubmed-4787342
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-47873422016-03-25 Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma Xiao-Wen, Chang Chen-Xi, Xu Yu-Qiang, Liu Cai, Qian Pharmacogn Mag Original Article BACKGROUND: In traditional Chinese medicine, Atractylodis rhizoma is the dried rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz. After being processed, the dryness of A. rhizoma decreased, and the function of tonifying spleen increased. Therefore, the processed A. rhizoma is the best choice of clinical application. As the main active components, polyethylene alkynes exhibits various desirable pharmacological effects including anti-inflammatory, anti-bacterial and anti-arrhythmia activity. However, there is no report on the pharmacokinetic comparisons of atractylodin, one of polyethylene alkynes, in bio-samples after oral administration of crude and processed A. rhizoma until now. The in vivo study of active components of A. rhizoma would be necessary and helpful for clinical application and clarification of processing principle. OBJECTIVE: To compare the pharmacokinetic parameters of atractylodin after oral administration of crude and processed A. rhizoma, and clarify the processing principle of A. rhizoma. MATERIALS AND METHODS: Plasma concentrations of atractylodin in rats were determined by reversed-phase high-performance liquid chromatogram and the main pharmacokinetic parameters were estimated with Drug and Statistics 2.0 Software Package (Chinese Pharmacological Society, Shanghai, China). RESULTS: The AUC(0−t), AUC(0→∞), T(max), and C(max) of processed A. rhizoma were increased significantly (P < 0.05) compared with that in crude A. rhizoma after using Student's t-test. CONCLUSIONS: Processing A. rhizoma with wheat bran by stir-frying can promote and accelerate the absorption of atractylodin. SUMMARY: In this paper, a RP-HPLC method with UV detection for quantification of atractylodin (a main active component in Atractylodis Rhizoma) in rat plasma has been developed and applied to a preliminary pharmacokinetic study of atractylodin after oral administration of crude and processed Atractylodis Rhizoma respectively. The result indicates that processing Atractylodis Rhizoma with wheat-bran can promote and accelerate the absorption of atractylodin. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4787342/ /pubmed/27019565 http://dx.doi.org/10.4103/0973-1296.176062 Text en Copyright: © Pharmacognosy Magazine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Xiao-Wen, Chang
Chen-Xi, Xu
Yu-Qiang, Liu
Cai, Qian
Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma
title Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma
title_full Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma
title_fullStr Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma
title_full_unstemmed Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma
title_short Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma
title_sort determination and pharmacokinetic comparisons of atractylodin after oral administration of crude and processed atractylodis rhizoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787342/
https://www.ncbi.nlm.nih.gov/pubmed/27019565
http://dx.doi.org/10.4103/0973-1296.176062
work_keys_str_mv AT xiaowenchang determinationandpharmacokineticcomparisonsofatractylodinafteroraladministrationofcrudeandprocessedatractylodisrhizoma
AT chenxixu determinationandpharmacokineticcomparisonsofatractylodinafteroraladministrationofcrudeandprocessedatractylodisrhizoma
AT yuqiangliu determinationandpharmacokineticcomparisonsofatractylodinafteroraladministrationofcrudeandprocessedatractylodisrhizoma
AT caiqian determinationandpharmacokineticcomparisonsofatractylodinafteroraladministrationofcrudeandprocessedatractylodisrhizoma