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A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex

The Mre11/Rad50 complex is a central player in various genome maintenance pathways. Here, we report a novel mode of nuclease action found for the Escherichia coli Mre11/Rad50 complex, SbcC(2)/D(2) complex (SbcCD). SbcCD cuts off the top of a cruciform DNA by making incisions on both strands and cont...

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Detalles Bibliográficos
Autores principales:	Lim, Chew Theng, Lai, Pey Jiun, Leach, David R. F., Maki, Hisaji, Furukohri, Asako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787754/ https://www.ncbi.nlm.nih.gov/pubmed/26319016 http://dx.doi.org/10.1093/nar/gkv855

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