The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation

Activation of NF-κB-dependent transcription represents an important hallmark of inflammation. While the acute inflammatory response is per se beneficial, it can become deleterious if its spatial and temporal profile is not tightly controlled. Classically, NF-κB activity is limited by cytoplasmic ret...

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Detalles Bibliográficos
Autores principales: Hochrainer, Karin, Pejanovic, Nadja, Olaseun, Victoria A., Zhang, Sheng, Iadecola, Costantino, Anrather, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787756/
https://www.ncbi.nlm.nih.gov/pubmed/26476452
http://dx.doi.org/10.1093/nar/gkv1064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787756/
https://www.ncbi.nlm.nih.gov/pubmed/26476452
http://dx.doi.org/10.1093/nar/gkv1064

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