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KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Latency-associated nuclear antigen (LANA) is central to episomal tethering, replication and transcriptional regulation of γ2-herpesviruses. LANA binds cooperatively to the terminal repeat (TR) region of the viral episome via adjacent LANA binding sites (LBS), but the molecular mechanism by which LAN...

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Detalles Bibliográficos
Autores principales:	Ponnusamy, Rajesh, Petoukhov, Maxim V., Correia, Bruno, Custodio, Tania F., Juillard, Franceline, Tan, Min, Pires de Miranda, Marta, Carrondo, Maria A., Simas, J. Pedro, Kaye, Kenneth M., Svergun, Dmitri I., McVey, Colin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787769/ https://www.ncbi.nlm.nih.gov/pubmed/26424851 http://dx.doi.org/10.1093/nar/gkv987

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