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Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi

TET proteins play a vital role in active DNA demethylation in mammals and thus have important functions in many essential cellular processes. The chemistry for the conversion of 5mC to 5hmC, 5fC and 5caC catalysed by TET proteins is similar to that of T to 5hmU, 5fU and 5caU catalysed by thymine-7-h...

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Detalles Bibliográficos
Autores principales:	Li, Wenjing, Zhang, Tianlong, Ding, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787775/ https://www.ncbi.nlm.nih.gov/pubmed/26429971 http://dx.doi.org/10.1093/nar/gkv979

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