Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells

The replication protein A (RPA)–ssDNA complex formed at arrested replication forks recruits key proteins to activate the ATR-CHK1 signalling cascade. When CHK1 is inhibited during DNA replication stress, RPA2 is extensively hyperphosphorylated. Here, we investigated the role of RPA2 hyperphosphoryla...

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Detalles Bibliográficos
Autores principales: Zuazua-Villar, Pedro, Ganesh, Anil, Phear, Geraldine, Gagou, Mary E., Meuth, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787776/
https://www.ncbi.nlm.nih.gov/pubmed/26271993
http://dx.doi.org/10.1093/nar/gkv835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787776/
https://www.ncbi.nlm.nih.gov/pubmed/26271993
http://dx.doi.org/10.1093/nar/gkv835

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